| n-3 fatty acid requirements of the newborn. | |
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MedLine Citation:
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PMID: 1491606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether docosahexaenoic acid (22:6n-3) is an essential nutrient for term or preterm infants, or if not, the quantity of dietary linolenic acid (18:3n-3) needed to support sufficient synthesis of 22:6n-3 for assimilation in the central nervous system is unknown. Infants fed formulas have lower plasma and red blood cell (RBC) levels of 22:6n-3 than breast fed infants. No relationship between the intake of 18:3n-3 in formula (0.8 or 4.5% of fatty acids, 18:2n-6/18:3n-3 ratio 35:1 or 7:1, respectively) and the infant's RBC 22:6n-3 was found. Premature infants (< 33 wk gestation) also showed a decrease in RBC 22:6n-3 during feeding with formula containing 18:3n-3 as the only n-3 fatty acid. However, a marked decrease in plasma and RBC 22:6n-3 occurred between premature birth and the start of full enteral feeding at 1-2 wk of age. This was not reversed by breast milk or formula feeding. Piglets, which are appropriate for studies of infant lipid metabolism, had decreased brain synaptic plasma membrane, retina and liver 22:6n-3 and increased 22:5n-6 when fed formula with 0.8% fatty acids (0.3% of kcal) as 18:3n-3. Formula with 4.0% fatty acids (1.7% of kcal) as 18:3n-3 resulted in similar accretion of 22:6n-3 in the organs compared to milk fed animals. The studies suggest the dietary requirement for 18:3n-3 in term animals in energy balance exceeds 0.3% diet kcal.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S M Innis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Lipids Volume: 27 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-03-01 Completed Date: 1993-03-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 879-85 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Docosahexaenoic Acids / blood, metabolism Erythrocytes / metabolism Fatty Acids, Omega-3 / administration & dosage* Gestational Age Humans Infant Infant Food Infant Nutritional Physiological Phenomena* Infant, Newborn Infant, Premature / blood Linolenic Acids / administration & dosage Milk, Human Nutritional Requirements* Parenteral Nutrition Swine |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Linolenic Acids; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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