Document Detail

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation.
MedLine Citation:
PMID:  22770766     Owner:  NLM     Status:  Publisher    
Neuroinflammation is present in the majority of acute and chronic neurological disorders. Excess or prolonged inflammation in the brain is thought to exacerbate neuronal damage and loss. Identifying modulators of neuroinflammation is an active area of study since it may lead to novel therapies. Omega-3 polyunsaturated fatty acids (n-3 PUFA) are anti-inflammatory in many non-neural tissues; their role in neuroinflammation is less studied. This review summarizes the relationship between n-3 PUFA and brain inflammation in animal models of brain injury and aging. Evidence by and large shows protective effects of n-3 PUFA in models of sickness behavior, stroke, aging, depression, Parkinson's disease, diabetes, and cytokine- and irradiation-induced cognitive impairments. However, rigorous studies that test the direct effects of n-3 PUFA in neuroinflammation in vivo are lacking. Future research in this area is necessary to determine if, and if so which, n-3 PUFA directly target brain inflammatory pathways. n-3 PUFA bioactive metabolites may provide novel therapeutic targets for neurological disorders with a neuroinflammatory component.
Sarah K Orr; Marc-Olivier Trépanier; Richard P Bazinet
Related Documents :
24331586 - Ghrelin as a starvation signal.
9366076 - Absorption and fate of l- and d-lactic acid in ruminants.
4031186 - Digestion and absorption of lipids and bile acids in sheep fed stearic acid, oleic acid...
16436846 - Effects of general anesthesia on anandamide blood levels in humans.
10227706 - Transport of pregabalin in rat intestine and caco-2 monolayers.
3350126 - Goniothalamicin and annonacin: bioactive acetogenins from goniothalamus giganteus (anno...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-4
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  -     ISSN:  1532-2823     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Schizotypal traits and neurocognitive functioning among nonclinical young adults.
Next Document:  Paraganglioma of the cauda equina region: Report of six cases and review of the literature.