Document Detail


n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization.
MedLine Citation:
PMID:  22020145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fish oil, enriched in bioactive n-3 polyunsaturated fatty acids (PUFA), has therapeutic value for the treatment of inflammation-associated disorders. The effects of n-3 PUFAs are pleiotropic and complex; hence, an understanding of their cellular targets and molecular mechanisms of action remains incomplete. Here we focus on recent data indicating n-3 PUFAs exert immunosuppressive effects on the function of effector and regulatory CD4(+) T cells. In addition, we also present emerging evidence that n-3 PUFAs have immunomodulatory effects on B cells. We then focus on one multifaceted mechanism of n-3 PUFAs, which is the alteration of the biophysical and biochemical organization of the plasma membrane. This mechanism is central for downstream signaling, eicosanoid production, transcriptional regulation and cytokine secretion. We highlight recent work demonstrating n-3 PUFA acyl chains in the plasma membrane target the lateral organization of membrane signaling assemblies (i.e. lipid rafts or signaling networks) and de novo phospholipid biosynthesis. We conclude by proposing new functional and mechanistic questions in this area of research that will aid in the development of fish oil as adjuvant therapy for treating unresolved chronic inflammation.
Authors:
Saame Raza Shaikh; Christopher A Jolly; Robert S Chapkin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-10-19
Journal Detail:
Title:  Molecular aspects of medicine     Volume:  33     ISSN:  1872-9452     ISO Abbreviation:  Mol. Aspects Med.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-04-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7603128     Medline TA:  Mol Aspects Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry & Molecular Biology and East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA. shaikhsa@ecu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / drug effects,  immunology
CD4-Positive T-Lymphocytes / drug effects,  immunology
Cell Membrane / drug effects*,  metabolism*
Fatty Acids, Omega-3 / pharmacology*
Humans
Immunologic Factors / pharmacology*
Lymphocytes / drug effects*,  immunology*
Membrane Microdomains / drug effects,  metabolism
Grant Support
ID/Acronym/Agency:
DK071707/DK/NIDDK NIH HHS; P30ES09106/ES/NIEHS NIH HHS; R01 AG/AR20651/AG/NIA NIH HHS; R15 AT006122-01/AT/NCCAM NIH HHS; R15AT006122/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Immunologic Factors
Comments/Corrections

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