| n-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization. | |
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MedLine Citation:
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PMID: 21798252 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is now well established that dietary lipids are incorporated into macrophage and T-cell membrane microdomains, altering their structure and function. Within cell membranes, there are specific detergent-resistant domains in which key signal transduction proteins are localized. These regions are classified as "lipid rafts". Rafts are composed mostly of cholesterol and sphingolipids and therefore do not integrate well into the fluid phospholipid bilayers causing them to form microdomains. Upon cell activation, rafts compartmentalize signal-transducing molecules, thus providing an environment conducive to signal transduction. In this review, we discuss recent novel data describing the effects of n-3 PUFA on alterations in the activation and functions of macrophages and T-cells. We believe that the modifications in these two disparate immune cell types are linked by fundamentally similar changes in membrane lipid composition and transmembrane signaling functions. We conclude that the outcomes of n-3 PUFA-mediated immune cell alterations may be beneficial (e.g., anti-inflammatory) or detrimental (e.g., loss of microbial immunity) depending upon the cell type interrogated. |
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Authors:
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David N McMurray; Diana L Bonilla; Robert S Chapkin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-20 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: - ISSN: 1873-2941 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, TX, United States; Program in Integrative Nutrition and Complex Diseases, Texas A&M Health Science Center, College Station, TX, United States; Center for Environmental and Rural Health, Texas A&M Health Science Center, College Station, College Station, TX, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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