Document Detail

n-3 Fatty acid supplementation in burned paediatric patients.
MedLine Citation:
PMID:  19681767     Owner:  NLM     Status:  MEDLINE    
AIM: To determine the effect of dietary supplementation with n-3 fatty acids (FA) in paediatric burned patients who had less than 20% of total body surface affected. METHODS: Burned patients were randomly assigned into two groups, one of them received a supplement of n-3 FA during 5 weeks; the other group was considered as not n-3 supplemented burned group. A third group of no burned patients was selected as control. Blood samples were collected at admission and in burned groups at the final of the study. Plasma and erythrocyte phospholipid FA composition and some biochemical parameters related to the clinical evolution: total plasma proteins and C3 and C4 complement proteins were determined. RESULTS: In the early post-burn patients, there is an increase in saturated and monounsaturated FAs in plasma phospholipids, and a decrease in polyunsaturated FAs compared with control. These alterations are in favour of proinflammatory response to burn injury. In n-3 FA supplemented group, these changes were further reverted, and a favourable response in the amount of total plasma proteins and in C3 and C4 proteins of the complement system was demonstrated. CONCLUSION: Dietary n-3 FA supplementation might be beneficial for patients suffering thermal injury.
M C Marín; N E Osimani; G E Rey; M J T de Alaniz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-13
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-06     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1982-7     Citation Subset:  IM    
Instituto de Investigaciones Bioquímicas de la Plata (INIBIOLP), CCT-La Plata CONICET-UNLP, Facultad de Ciencias Médicas, La Plata, Argentina.
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MeSH Terms
Analysis of Variance
Blood Proteins / analysis
Burns / diet therapy*
Child, Preschool
Dietary Supplements*
Fatty Acids / blood
Fatty Acids, Omega-3 / therapeutic use*
Phospholipids / blood,  chemistry
Treatment Outcome
Reg. No./Substance:
0/Blood Proteins; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Phospholipids

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