Document Detail


n-3 fatty acids and periodontitis in US adults.
MedLine Citation:
PMID:  21034880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Periodontitis is a common, chronic inflammatory disease. Although n-3 fatty acids have anti-inflammatory properties, it is unclear whether n-3 fatty acids can treat or prevent periodontitis.
METHOD: We studied 9,182 adults aged 20 years and older who participated in the National Health and Nutrition Examination Survey between 1999 and 2004. Periodontitis was assessed by dental exam and was defined as >4 mm pocket depth and >3 mm attachment loss in any one tooth. Intake of n-3 fatty acids was assessed by 24-hour dietary recall. We used multivariable logistic regression to estimate the associations between periodontitis and intakes of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and linolenic acid (LNA).
RESULTS: The weighted prevalence and 95% confidence interval (CI) of periodontitis was 8.2% (95% CI 7.0 to 9.4). Compared with the lowest tertiles, the adjusted odds ratios for periodontitis associated with the highest tertiles of dietary n-3 intake were 0.78 (95% CI 0.61 to 1.00; P=0.009) for DHA, 0.85 (95% CI 0.67 to 1.08; P=0.10) for EPA, and 0.86 (95% CI 0.60 to 1.23; P=0.28) for LNA. The associations were little changed by multivariable adjustment or exclusion of individuals reporting use of dietary supplements containing DHA, EPA, or LNA.
CONCLUSIONS: In this nationally representative sample, higher dietary intakes of DHA and, to a lesser degree, EPA, were associated with lower prevalence of periodontitis. Interventional studies are needed to confirm the potential protective effects of n-3 fatty acids on periodontitis.
Authors:
Asghar Z Naqvi; Catherine Buettner; Russell S Phillips; Roger B Davis; Kenneth J Mukamal
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  110     ISSN:  1878-3570     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-11-30     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1669-75     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Anti-Inflammatory Agents / administration & dosage*
Dietary Fats, Unsaturated / administration & dosage*
Docosahexaenoic Acids / administration & dosage
Dose-Response Relationship, Drug
Eicosapentaenoic Acid / administration & dosage
Fatty Acids, Omega-3 / administration & dosage*
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Nutrition Surveys
Odds Ratio
Periodontitis / epidemiology,  prevention & control*
Prevalence
Sex Factors
Smoking / adverse effects
Socioeconomic Factors
Young Adult
alpha-Linolenic Acid / administration & dosage
Grant Support
ID/Acronym/Agency:
5 T32 AT000051/AT/NCCAM NIH HHS; K23 AR055664/AR/NIAMS NIH HHS; K23 AR055664-01A1/AR/NIAMS NIH HHS; K23 AR055664-02/AR/NIAMS NIH HHS; K23 AR055664-03/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 0RBV727H71/alpha-Linolenic Acid; 25167-62-8/Docosahexaenoic Acids; AAN7QOV9EA/Eicosapentaenoic Acid
Comments/Corrections
Comment In:
J Am Diet Assoc. 2010 Nov;110(11):1650-2   [PMID:  21034877 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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