| n-3 fatty acids and periodontitis in US adults. | |
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MedLine Citation:
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PMID: 21034880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Periodontitis is a common, chronic inflammatory disease. Although n-3 fatty acids have anti-inflammatory properties, it is unclear whether n-3 fatty acids can treat or prevent periodontitis. METHOD: We studied 9,182 adults aged 20 years and older who participated in the National Health and Nutrition Examination Survey between 1999 and 2004. Periodontitis was assessed by dental exam and was defined as >4 mm pocket depth and >3 mm attachment loss in any one tooth. Intake of n-3 fatty acids was assessed by 24-hour dietary recall. We used multivariable logistic regression to estimate the associations between periodontitis and intakes of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and linolenic acid (LNA). RESULTS: The weighted prevalence and 95% confidence interval (CI) of periodontitis was 8.2% (95% CI 7.0 to 9.4). Compared with the lowest tertiles, the adjusted odds ratios for periodontitis associated with the highest tertiles of dietary n-3 intake were 0.78 (95% CI 0.61 to 1.00; P=0.009) for DHA, 0.85 (95% CI 0.67 to 1.08; P=0.10) for EPA, and 0.86 (95% CI 0.60 to 1.23; P=0.28) for LNA. The associations were little changed by multivariable adjustment or exclusion of individuals reporting use of dietary supplements containing DHA, EPA, or LNA. CONCLUSIONS: In this nationally representative sample, higher dietary intakes of DHA and, to a lesser degree, EPA, were associated with lower prevalence of periodontitis. Interventional studies are needed to confirm the potential protective effects of n-3 fatty acids on periodontitis. |
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Authors:
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Asghar Z Naqvi; Catherine Buettner; Russell S Phillips; Roger B Davis; Kenneth J Mukamal |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 110 ISSN: 1878-3570 ISO Abbreviation: J Am Diet Assoc Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-30 Revised Date: 2013-01-14 |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: United States |
Other Details:
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Languages: eng Pagination: 1669-75 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Harvard Medical School, and a hospitalist, Beth Israel Deaconess Medical Center, Boston, MA, USA. asghar_naqvi@hms.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Aged, 80 and over Anti-Inflammatory Agents / administration & dosage* Dietary Fats, Unsaturated / administration & dosage* Docosahexaenoic Acids / administration & dosage Dose-Response Relationship, Drug Eicosapentaenoic Acid / administration & dosage Fatty Acids, Omega-3 / administration & dosage* Female Humans Logistic Models Male Middle Aged Multivariate Analysis Nutrition Surveys Odds Ratio Periodontitis / epidemiology, prevention & control* Prevalence Sex Factors Smoking / adverse effects Socioeconomic Factors Young Adult alpha-Linolenic Acid / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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5 T32 AT000051/AT/NCCAM NIH HHS; K23 AR055664/AR/NIAMS NIH HHS; K23 AR055664-01A1/AR/NIAMS NIH HHS; K23 AR055664-02/AR/NIAMS NIH HHS; K23 AR055664-03/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Omega-3; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid |
| Comments/Corrections | |
Comment In:
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J Am Diet Assoc. 2010 Nov;110(11):1650-2
[PMID:
21034877
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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