Document Detail

The mysteries of sexual identity. The germ cell's perspective.
MedLine Citation:
PMID:  17446389     Owner:  NLM     Status:  MEDLINE    
Animal germ cells differentiate as sperm or eggs, depending on their sex. Somatic signals tell germ cells whether they reside in a male or female body, but how do germ cells interpret those external cues to acquire their own sexual identity? A critical aspect of a germ cell's sexual puzzle is that the sperm/egg decision is closely linked to the cell-cycle decision between mitosis and meiosis. Molecular studies have begun to tease apart the regulators of both decisions, an essential step toward understanding the regulatory logic of this fundamental question of germ cell biology.
Judith Kimble; David C Page
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  316     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  400-1     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
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MeSH Terms
Cell Differentiation
Cell Lineage
Germ Cells / cytology*,  physiology
Models, Biological
Ovum / cytology
Spermatozoa / cytology

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