| The mysteries of sexual identity. The germ cell's perspective. | |
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MedLine Citation:
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PMID: 17446389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Animal germ cells differentiate as sperm or eggs, depending on their sex. Somatic signals tell germ cells whether they reside in a male or female body, but how do germ cells interpret those external cues to acquire their own sexual identity? A critical aspect of a germ cell's sexual puzzle is that the sperm/egg decision is closely linked to the cell-cycle decision between mitosis and meiosis. Molecular studies have begun to tease apart the regulators of both decisions, an essential step toward understanding the regulatory logic of this fundamental question of germ cell biology. |
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Authors:
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Judith Kimble; David C Page |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 316 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 400-1 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. jekimble@wisc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Lineage Female Germ Cells / cytology*, physiology Male Meiosis* Mitosis* Models, Biological Oogenesis Ovum / cytology Spermatogenesis Spermatozoa / cytology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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