Document Detail


Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes.
MedLine Citation:
PMID:  23213046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: These findings suggest that HBV hepatotropism is mediated by the highly selective expression of a yet unknown receptor* on differentiated hepatocytes, while species specificity of the HBV infection requires selective downstream events, e.g., the presence of host dependency or the absence of host restriction factors. The criteria defined here will allow narrowing down reasonable receptor candidates and provide a binding assay for HBV-receptor expression screens in hepatic cells.
Authors:
Anja Meier; Stefan Mehrle; Thomas S Weiss; Walter Mier; Stephan Urban
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-26     Completed Date:  2013-08-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Dogs
Fluorescein-5-isothiocyanate / diagnostic use
Fluorescent Dyes / diagnostic use
Hep G2 Cells
Hepatitis B virus / metabolism*
Hepatocytes / immunology,  metabolism*
Humans
Kinetics
Mice
Myristic Acid / metabolism
Protein Precursors / metabolism
Rabbits
Rats
Receptors, Virus / metabolism*
Species Specificity
Tupaia
Viral Envelope Proteins / physiology*
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 0/L protein, hepatitis B virus; 0/Protein Precursors; 0/Receptors, Virus; 0/Viral Envelope Proteins; 0I3V7S25AW/Myristic Acid; I223NX31W9/Fluorescein-5-isothiocyanate
Comments/Corrections
Comment In:
Hepatology. 2013 Jul;58(1):9-12   [PMID:  23390015 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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