Document Detail


The myorelaxant effect of theophylline on smooth muscle cells of the afferent arterioles and glomerular tuft.
MedLine Citation:
PMID:  658136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Theophylline, infused i.v. into rats increased the diameter of the glomerular afferent arterioles by 35.78%; when added to a suspension of isolated glomeruli, it increased the diameter of the capillary tuft within the glomerulus by 25-30%. These variations in diameter can be explained by the myorelaxant effect of theophylline on the smooth contractile fibers present in the arteriolar cells and in certain glomerular cells, such as the mesangial cells. These observations explain, in part, the marked changes in glomerular hemodynamics caused by the injection of theophylline.
Authors:
J Cambar; J Saurel; J Canellas
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  49     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / drug effects
Kidney Glomerulus / blood supply,  drug effects*
Male
Muscle Contraction / drug effects*
Muscle Relaxation / drug effects*
Muscle, Smooth / drug effects*
Rats
Theophylline / pharmacology*
Chemical
Reg. No./Substance:
58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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