| The myorelaxant effect of theophylline on smooth muscle cells of the afferent arterioles and glomerular tuft. | |
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MedLine Citation:
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PMID: 658136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theophylline, infused i.v. into rats increased the diameter of the glomerular afferent arterioles by 35.78%; when added to a suspension of isolated glomeruli, it increased the diameter of the capillary tuft within the glomerulus by 25-30%. These variations in diameter can be explained by the myorelaxant effect of theophylline on the smooth contractile fibers present in the arteriolar cells and in certain glomerular cells, such as the mesangial cells. These observations explain, in part, the marked changes in glomerular hemodynamics caused by the injection of theophylline. |
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Authors:
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J Cambar; J Saurel; J Canellas |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 49 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 193-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / drug effects Kidney Glomerulus / blood supply, drug effects* Male Muscle Contraction / drug effects* Muscle Relaxation / drug effects* Muscle, Smooth / drug effects* Rats Theophylline / pharmacology* |
| Chemical | |
Reg. No./Substance:
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58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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