Document Detail

The myomatous erythrocytosis syndrome: a review.
MedLine Citation:
PMID:  7501327     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the literature regarding the association of erythrocytosis and uterine myomas, because of the lack of anemia in many women with menorrhagia and fibroids. DATA SOURCES: We searched the MEDLINE English-language data base and reference lists to find articles referring to the myomatous erythrocytosis syndrome. METHODS OF STUDY SELECTION: All case reports of the myomatous erythrocytosis syndrome were included in this review. DATA EXTRACTION AND SYNTHESIS: Symptoms, laboratory studies, histopathologic findings, and possible etiologies for each of 31 cases were extracted. The symptoms described were most commonly related to the presence of a myomatous uterus with occasional manifestations of erythrocytosis. A routine complete blood count was used to diagnose erythrocytosis in all cases. Evaluation of the bone marrow, blood volume, erythrocyte life span, and erythropoietin activity have all been used to help confirm the diagnosis. The histopathologic findings were similar to those commonly seen in myomas. Possible factors in the etiology of this syndrome include: vascular shunts within the myoma, large uterine size, myoma site, change in red cell life span, alteration in erythropoietin production by the kidney, and autonomous secretion of erythropoietin or an erythropoietin-like substrate by the myomatous uterus. CONCLUSION: Elevated levels of erythropoietin accompany the myomatous erythrocytosis syndrome. All myomas may alter erythropoietin production, causing varying degrees of erythrocytosis, which could explain the lack of anticipated anemia despite the presence of menorrhagia. Use of the currently available, highly sensitive radioimmunoassay for erythropoietin should help in our understanding of the role uterine myomas play in erythropoiesis.
M LevGur; M D Levie
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  86     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-16     Completed Date:  1996-01-16     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1026-30     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York, USA.
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MeSH Terms
Leiomyoma* / diagnosis,  etiology
Polycythemia* / diagnosis,  etiology
Uterine Neoplasms* / diagnosis,  drug therapy

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