| The myocardial interstitium: its structure and its role in ionic exchange. | |
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MedLine Citation:
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PMID: 4824287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The structures present in the rabbit myocardial interstitium have been defined and quantified. Stereological methods were used for the quantification. The extracellular space contains abundant ground substance (23%) distributed in a homogeneous mat throughout the space and within the T tubules. The remainder of the space contains 59% blood vessels, 6% "empty" space, 4.0% collagen, and 7.0% connective tissue cells. The arrangement of the interstitium in relation to the myocardial cells and the capillaries has been described. In addition, the extracellular space was measured using extracellular markers: (14)C sucrose (neutrally charged), (35)SO(4) (negatively charged), and (140)La (positively charged). The La(+++) space differed markedly from the other two (P << 0.001), indicating extensive binding of La(+++) to polyanionic extracellular structures. Cetylpyridinium chloride, a cationic detergent specific for polysaccharides, caused precipitation of the ground substance and marked decrease in the La(+++) space. This study indicates the considerable structural complexity of the interstitium. The effects of an abundant negatively charged protein-polysaccharide within the interstitium has been discussed in terms of cation exchange in arterially perfused tissue. |
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Authors:
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J S Frank; G A Langer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of cell biology Volume: 60 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1974 Mar |
Date Detail:
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Created Date: 1974-06-20 Completed Date: 1974-06-20 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 586-601 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites Biological Transport Carbon Radioisotopes Detergents Extracellular Space Heart / anatomy & histology* Histocytochemistry Lanthanum / metabolism Microscopy, Electron Myocardium / cytology, metabolism* Perfusion Rabbits Radioisotopes Receptors, Drug Sucrose / metabolism Sulfates / metabolism Sulfur Radioisotopes |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Detergents; 0/Radioisotopes; 0/Receptors, Drug; 0/Sulfates; 0/Sulfur Radioisotopes; 57-50-1/Sucrose; 7439-91-0/Lanthanum |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1974 by The Rockefeller University Press Received Day: 9 Month: 8 Year: 1973 Revision Received Day: 8 Month: 11 Year: 1973 Print publication date: Day: 1 Month: 3 Year: 1974 Volume: 60 Issue: 3 First Page: 586 Last Page: 601 ID: 2109249 PubMed Id: 4824287 |
| THE MYOCARDIAL INTERSTITIUM: ITS STRUCTURE AND ITS ROLE IN IONIC EXCHANGE | |
| J. S. Frank | |
| G. A. Langer | |
| From the Departments of Medicine and Physiology and the Los Angeles County Heart Association Cardiovascular Research Laboratory, University of California at Los Angeles, Center for the Health Sciences, Los Angeles, California 90024 |
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