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The myocardial interstitium: its structure and its role in ionic exchange.
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MedLine Citation:
PMID:  4824287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The structures present in the rabbit myocardial interstitium have been defined and quantified. Stereological methods were used for the quantification. The extracellular space contains abundant ground substance (23%) distributed in a homogeneous mat throughout the space and within the T tubules. The remainder of the space contains 59% blood vessels, 6% "empty" space, 4.0% collagen, and 7.0% connective tissue cells. The arrangement of the interstitium in relation to the myocardial cells and the capillaries has been described. In addition, the extracellular space was measured using extracellular markers: (14)C sucrose (neutrally charged), (35)SO(4) (negatively charged), and (140)La (positively charged). The La(+++) space differed markedly from the other two (P << 0.001), indicating extensive binding of La(+++) to polyanionic extracellular structures. Cetylpyridinium chloride, a cationic detergent specific for polysaccharides, caused precipitation of the ground substance and marked decrease in the La(+++) space. This study indicates the considerable structural complexity of the interstitium. The effects of an abundant negatively charged protein-polysaccharide within the interstitium has been discussed in terms of cation exchange in arterially perfused tissue.
Authors:
J S Frank; G A Langer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  60     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1974 Mar 
Date Detail:
Created Date:  1974-06-20     Completed Date:  1974-06-20     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-601     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Biological Transport
Carbon Radioisotopes
Detergents
Extracellular Space
Heart / anatomy & histology*
Histocytochemistry
Lanthanum / metabolism
Microscopy, Electron
Myocardium / cytology,  metabolism*
Perfusion
Rabbits
Radioisotopes
Receptors, Drug
Sucrose / metabolism
Sulfates / metabolism
Sulfur Radioisotopes
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Detergents; 0/Radioisotopes; 0/Receptors, Drug; 0/Sulfates; 0/Sulfur Radioisotopes; 57-50-1/Sucrose; 7439-91-0/Lanthanum
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Full Text
Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1974 by The Rockefeller University Press
Received Day: 9 Month: 8 Year: 1973
Revision Received Day: 8 Month: 11 Year: 1973
Print publication date: Day: 1 Month: 3 Year: 1974
Volume: 60 Issue: 3
First Page: 586 Last Page: 601
ID: 2109249
PubMed Id: 4824287

THE MYOCARDIAL INTERSTITIUM: ITS STRUCTURE AND ITS ROLE IN IONIC EXCHANGE
J. S. Frank
G. A. Langer
From the Departments of Medicine and Physiology and the Los Angeles County Heart Association Cardiovascular Research Laboratory, University of California at Los Angeles, Center for the Health Sciences, Los Angeles, California 90024


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