| The myocardial heat shock response following sodium salicylate treatment. | |
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MedLine Citation:
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PMID: 11048658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In cultured cells, salicylate has been shown to potentiate the induction of Hsp72 so that a mild heat stress (40 degrees C) in the presence of salicylate induces an Hsp72 response that is similar to a severe heat stress (42 degrees C). To determine whether salicylate can potentiate the myocardial Hsp70 response in vivo and confer protection from an ischemic stress, male Sprague-Dawley rats (250-300 g) were placed into 5 groups: (1) control, (2) salicylate only (400 mg/kg), (3) mild heat stress (40 degrees C for 15 minutes), (4) mild heat stress plus salicylate, and (5) severe heat stress (42 degrees C for 15 minutes). Twenty-four hours following salicylate treatment and/or heat stress, animals were anesthetized, their hearts rapidly isolated, and hemodynamic function evaluated using the Langendorff technique. Hsp72 content was subsequently assessed by Western blotting. Although salicylate in combination with a mild heat stress induced heat shock factor activation, only the hearts from severely heat-stressed animals (42 degrees C) demonstrated a significantly elevated myocardial Hsp72 content and a significantly enhanced postischemic recovery of left ventricular developed pressure and rates of contraction and relaxation. These results support the role for Hsp72 as a protective protein and suggest that neither salicylate treatment alone nor salicylate in combination with a mild heat stress potentiates the myocardial Hsp72 response. |
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Authors:
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M Locke; J Atance |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell stress & chaperones Volume: 5 ISSN: 1355-8145 ISO Abbreviation: Cell Stress Chaperones Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-05 Completed Date: 2001-02-08 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 9610925 Medline TA: Cell Stress Chaperones Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-68 Citation Subset: IM |
Affiliation:
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Faculty of Physical Education and Health, University of Toronto, Ontario, Canada. marius.locke@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Coronary Circulation HSP70 Heat-Shock Proteins / analysis Heat-Shock Response / drug effects* Hemodynamics Male Myocardial Reperfusion Injury / metabolism Myocardium / metabolism* Rats Rats, Sprague-Dawley Sodium Salicylate / pharmacology* Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 54-21-7/Sodium Salicylate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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