| A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function. | |
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MedLine Citation:
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PMID: 19735726 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Circulating levels of myeloperoxidase (MPO), a heme enzyme released upon activation of polymorphonuclear neutrophils, predict adverse outcome in patients with impaired left ventricular (LV) function. The MPO -463 G/A promoter polymorphism (rs 2333227) regulates MPO transcription, with the G allele being linked to increased protein expression. The aim of this study was to assess the prognostic information derived from the -463 G/A MPO polymorphism on outcomes of patients with impaired LV function. The -463 G/A promoter MPO genotype as well as MPO plasma levels were determined in 116 patients with impaired LV function. Patients were prospectively followed for a median of 1050 days. The GG genotype was associated with a decrease in overall survival (chi(2) 5.80; p=0.016). This association remained after multivariate adjustment for plasma levels of NT-proBNP, creatinine, hsCRP, and MPO; leukocyte count; and LV function (hazard ratio 3.16 (95% CI 1.17-8.53), p=0.024) and for classical cardiovascular risk factors (hazard ratio 2.88 (95% CI 1.13-7.33), p=0.026). Interestingly, we observed no association of the MPO polymorphism with total MPO protein concentration or MPO activity in plasma. The -463 G/A MPO polymorphism is linked to adverse clinical outcome of patients with impaired LV function. Further studies are needed to elucidate the value of this polymorphism for risk stratification. |
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Authors:
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Volker Rudolph; Tanja K Rudolph; Lukas Kubala; Navina Clauberg; Renke Maas; Michaela Pekarova; Anna Klinke; Denise Lau; Katalin Szöcs; Thomas Meinertz; Rainer H Böger; Stephan Baldus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-06 |
Journal Detail:
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Title: Free radical biology & medicine Volume: 47 ISSN: 1873-4596 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 1584-90 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany. v.rudolph@uke.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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