Document Detail


PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors.
MedLine Citation:
PMID:  12712134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was conducted to evaluate the different mutations of p53 and compare p53 expression in gynecologic tumors in African American and Chinese women. METHOD: Tumor samples were collected from Atlanta, Ga, hospitals and National Taiwan University Hospital, Taiwan. Samples were examined for different mutations using electrophoretic variants after single-stranded conformational analysis (SSCA). Cell lines obtained from the American Type Culture Collection were also used. RESULTS: Mutations were identified in the gene for the tumor protein p53 at codons 156, 157, 176, 183, 246, and 248 at sites predicted to disrupt DNA binding. Collectively, an altered p53 status was found in about 28% of all tumors with similar frequencies observed between the African American and Chinese women. African American or Chinese women did not have common polymorphism. CONCLUSION: This study showed that in mutations in the PTEN/MMAC1 gene correlated inversely with an altered p53 status. Similar findings were found in 2 tumor cell lines examined. As p53 changes are associated with late stage cancers, we favor the possibility that in certain tumor subtypes, PTEN/MMAC1 genes alteration may be useful clinically in the evaluation of the tumor.
Authors:
Emmanuel O Soyoola; Roland A Pattillo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S33-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
Asian Continental Ancestry Group / genetics
Base Sequence / genetics
Codon / genetics
Female
Gene Frequency
Genital Neoplasms, Female / genetics*
Humans
Molecular Sequence Data
Mutation*
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases / genetics*
Polymorphism, Genetic*
Tumor Suppressor Protein p53 / genetics*
Tumor Suppressor Proteins / genetics*
Chemical
Reg. No./Substance:
0/Codon; 0/Tumor Suppressor Protein p53; 0/Tumor Suppressor Proteins; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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