Document Detail

PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors.
MedLine Citation:
PMID:  12712134     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was conducted to evaluate the different mutations of p53 and compare p53 expression in gynecologic tumors in African American and Chinese women. METHOD: Tumor samples were collected from Atlanta, Ga, hospitals and National Taiwan University Hospital, Taiwan. Samples were examined for different mutations using electrophoretic variants after single-stranded conformational analysis (SSCA). Cell lines obtained from the American Type Culture Collection were also used. RESULTS: Mutations were identified in the gene for the tumor protein p53 at codons 156, 157, 176, 183, 246, and 248 at sites predicted to disrupt DNA binding. Collectively, an altered p53 status was found in about 28% of all tumors with similar frequencies observed between the African American and Chinese women. African American or Chinese women did not have common polymorphism. CONCLUSION: This study showed that in mutations in the PTEN/MMAC1 gene correlated inversely with an altered p53 status. Similar findings were found in 2 tumor cell lines examined. As p53 changes are associated with late stage cancers, we favor the possibility that in certain tumor subtypes, PTEN/MMAC1 genes alteration may be useful clinically in the evaluation of the tumor.
Emmanuel O Soyoola; Roland A Pattillo
Related Documents :
17269744 - Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytot...
11423984 - Distinct pattern of p53 phosphorylation in human tumors.
17404014 - Apoptotic effect of celecoxib dependent upon p53 status in human ovarian cancer cells.
10813394 - The nuclear matrix as a target for viral and cellular oncogenes.
15018124 - Primitive neuroectodermal tumors, embryonal tumors, and other small cell and poorly dif...
10982354 - Induction of cd8 t cells by vaccination with recombinant adenovirus expressing human pa...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  188     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-24     Completed Date:  2003-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S33-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group / genetics
Asian Continental Ancestry Group / genetics
Base Sequence / genetics
Codon / genetics
Gene Frequency
Genital Neoplasms, Female / genetics*
Molecular Sequence Data
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases / genetics*
Polymorphism, Genetic*
Tumor Suppressor Protein p53 / genetics*
Tumor Suppressor Proteins / genetics*
Reg. No./Substance:
0/Codon; 0/Tumor Suppressor Protein p53; 0/Tumor Suppressor Proteins; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC protein, human; EC Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal blood lead effects on infant intelligence at age 7 months.
Next Document:  Racial disparities in reproductive health outcomes.