Document Detail


The mutagenic effect of carbimazol and methylthiouracil detected by the transplacentar micronucleus test.
MedLine Citation:
PMID:  7209357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mutagenic effect of carbimazol and methylthiouracil on mice fetal blood in the 15th and 16th day of intrauterine life, as compared to the effect on maternal bone marrow and control animals, was studied using the micronucleus test. The incidence of micronucleated cells was significantly higher in the fetal blood than in the maternal bone marrow. The finding demonstrates that the method of transplacentar mutagenesis is a reliable test for estimating the mutagenic risk of such drugs as carbimazol and methylthiouracil in current therapeutical use.
Authors:
D Ioan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinologie     Volume:  18     ISSN:  0253-1801     ISO Abbreviation:  Endocrinologie     Publication Date:    1980 Oct-Dec
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7509386     Medline TA:  Endocrinologie     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow / drug effects
Carbimazole / pharmacology*
Cell Nucleus / drug effects*
Erythrocytes / drug effects
Female
Fetal Blood / cytology,  drug effects
Male
Maternal-Fetal Exchange
Methylthiouracil / pharmacology*
Mice
Mutagenicity Tests / methods
Pregnancy
Chemical
Reg. No./Substance:
22232-54-8/Carbimazole; 56-04-2/Methylthiouracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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