Document Detail


The mutagenic and cell transforming properties of shikimic acid and some of its bacterial and mammalian metabolites.
MedLine Citation:
PMID:  6362076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Known and proposed metabolites of shikimic acid were synthesised, characterised and tested for genotoxic activity using the Salmonella/mammalian microsome mutagenicity test, the bacterial fluctuation mutagenicity test and the BHK 21 cell transformation test. Under the conditions used, none of these compounds showed any activity. However, shikimic acid itself was active in the BHK 21 cell transformation assay. It therefore seems unlikely that shikimic acid is a carcinogenic initiating agent, but it may act as a carcinogen-promoting agent in the bracken fern (Pteridium aquilinum).
Authors:
R S Jones; M Ali; C Ioannides; J A Styles; J Ashby; J Sulej; D V Parke
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  19     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:    1983 Oct-Nov
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biotransformation
Cell Line
Cell Transformation, Neoplastic / drug effects*
Cricetinae
Male
Mesocricetus
Microsomes, Liver / metabolism
Mutagenicity Tests
Mutagens*
Rats
Rats, Inbred Strains
Salmonella typhimurium / genetics
Shikimic Acid / metabolism,  toxicity*
Chemical
Reg. No./Substance:
0/Mutagens; 138-59-0/Shikimic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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