Document Detail

The muscle pattern of a segment of Drosophila may be determined by neurons and not by contributing myoblasts.
MedLine Citation:
PMID:  3085954     Owner:  NLM     Status:  MEDLINE    
Each segment of Drosophila has a characteristic pattern of muscles. Like the segments of the cuticle and the central nervous system, the muscle pattern is ultimately dependent on the deployment of selector genes such as elements of the bithorax complex. We use nuclear transplantation to make genetic mosaics in which the donor, but not the host, is mutant for part of the bithorax complex. Making use of a muscle pattern that is found only in the male, we ask which cells have to be mutant in order to obtain mutant muscles and find that these crucial cells do not contribute to the muscles themselves. The evidence implicates neurons that innervate the muscles. Our hypothesis is that the sex and segmental identity of the motor or neurosecretory neurons determine the development of muscle pattern.
P A Lawrence; P Johnston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell     Volume:  45     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-13     Citation Subset:  IM    
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MeSH Terms
Drosophila melanogaster / embryology*,  genetics
Embryonic Induction
Epidermis / embryology
Motor Neurons / physiology*
Muscles / embryology*,  innervation
Nuclear Transfer Techniques

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