| A murine model of myocardial microvascular thrombosis. | |
| | |
MedLine Citation:
|
PMID: 10487767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Disorders of hemostasis lead to vascular pathology. Endothelium-derived gene products play a critical role in the formation and degradation of fibrin. We sought to characterize the importance of these locally produced factors in the formation of fibrin in the cardiac macrovasculature and microvasculature. This study used mice with modifications of the thrombomodulin (TM) gene, the tissue-type plasminogen activator (tPA) gene, and the urokinase-type plasminogen activator (uPA) gene. The results revealed that tPA played the most important role in local regulation of fibrin deposition in the heart, with lesser contributions by TM and uPA (least significant). Moreover, a synergistic relationship in fibrin formation existed in mice with concomitant modifications of tPA and TM, resulting in myocardial necrosis and depressed cardiac function. The data were fit to a statistical model that may offer a foundation for examination of hemostasis-regulating gene interactions. |
| | |
Authors:
|
P D Christie; J M Edelberg; M H Picard; A S Foulkes; W Mamuya; H Weiler-Guettler; R H Rubin; P Gilbert; R D Rosenberg |
Related Documents
:
|
18941827 - Evolution and regulation of the downstream gene of hypoxia-inducible factor-1alpha in n... 1531537 - Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic f... 18425117 - A crucial role of a high mobility group protein hmga2 in cardiogenesis. 15907457 - Comparison of the four mouse fasciclin-containing genes expression patterns during valv... 10189707 - Differential light regulation of the rbcs gene expression in two cell lines of the live... 21674037 - Role of ox-papcs in the differentiation of mesenchymal stem cells (mscs) and runx2 and ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 104 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1999 Sep |
Date Detail:
|
Created Date: 1999-10-04 Completed Date: 1999-10-04 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 533-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cells, Cultured Coronary Thrombosis / genetics, metabolism*, pathology Disease Models, Animal* Endothelium, Vascular / metabolism, pathology Fibrin / biosynthesis* Fibrosis Genetic Predisposition to Disease Genotype Hemostasis Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microcirculation Myocardium / pathology* Thrombomodulin / deficiency, genetics, physiology* Tissue Plasminogen Activator / deficiency, genetics, physiology* Urokinase-Type Plasminogen Activator / deficiency, genetics, physiology* Ventricular Dysfunction, Left / genetics, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
|
HL-07604/HL/NHLBI NIH HHS; HL-41484/HL/NHLBI NIH HHS; P01-41484//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Thrombomodulin; 9001-31-4/Fibrin; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp aroun...
Next Document: Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation.