Document Detail

The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus.
MedLine Citation:
PMID:  8288247     Owner:  NLM     Status:  MEDLINE    
Interleukin-8 (IL-8), a member of the chemokine alpha subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL-8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM +/- 1 standard error) from the centromere: Mylf--7.9 +/- 2.7--Lsh-Ity-Bcg--1.9 +/- 1.4--Il8rb--1.9 +/- 1.4--Vil-- 5.9 +/- 2.3--Acrg--2.9 +/- 1.7--Bcl-2.
D P Cerretti; N Nelson; C J Kozlosky; P J Morrissey; N G Copeland; D J Gilbert; N A Jenkins; J K Dosik; B A Mock
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  18     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-3     Citation Subset:  IM    
Immunex Corporation, Seattle, Washington 98101.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Immunity, Innate / genetics
Molecular Sequence Data
Receptors, Interleukin / genetics*,  isolation & purification*
Receptors, Interleukin-8A
Receptors, Interleukin-8B
Grant Support
N01-CB-21075/CB/NCI NIH HHS; N01-CO-74101/CO/NCI NIH HHS
Reg. No./Substance:
0/Receptors, Interleukin; 0/Receptors, Interleukin-8A; 0/Receptors, Interleukin-8B; 9007-49-2/DNA

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