Document Detail


The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus.
MedLine Citation:
PMID:  8288247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-8 (IL-8), a member of the chemokine alpha subfamily, is a chemoattractant for neutrophils. Cell surface receptors for IL-8 have been cloned from rabbits and humans. Two related but different IL-8 receptors (IL-8R) have been characterized from humans. IL-8RA and IL-8RB bind IL-8 at high affinity but IL-8RB also binds GRO/MGSA and NAP-2 at high affinity. Using the human IL-8RB cDNA as a probe, we have determined that the homologous murine gene maps near the Ity-Lsh-Bcg disease resistance locus. A murine homologue of the human IL-8RB was isolated from a genomic library. This gene would encode a protein of 359 amino acids and would have a 68 and 71% amino acid identity with human IL-8RA and IL-8RB, respectively. Additional mapping data using the murine gene revealed the following genetic distances (in cM +/- 1 standard error) from the centromere: Mylf--7.9 +/- 2.7--Lsh-Ity-Bcg--1.9 +/- 1.4--Il8rb--1.9 +/- 1.4--Vil-- 5.9 +/- 2.3--Acrg--2.9 +/- 1.7--Bcl-2.
Authors:
D P Cerretti; N Nelson; C J Kozlosky; P J Morrissey; N G Copeland; D J Gilbert; N A Jenkins; J K Dosik; B A Mock
Related Documents :
9325057 - Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis ...
11714437 - A novel renal carcinoma predisposing gene of the nihon rat maps on chromosome 10.
10458907 - Novel human and mouse homologs of saccharomyces cerevisiae dna polymerase eta.
11574157 - Human monocyte x mouse melanoma fusion hybrids express human gene.
10095117 - Characterisation of novel plant genes encoding mekk/ste11 and raf-related protein kinases.
1923817 - Demonstration of a divergent transcript from the bidirectional heavy chain immunoglobul...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  18     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-3     Citation Subset:  IM    
Affiliation:
Immunex Corporation, Seattle, Washington 98101.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/L23637
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
DNA
Humans
Immunity, Innate / genetics
Mice
Molecular Sequence Data
Receptors, Interleukin / genetics*,  isolation & purification*
Receptors, Interleukin-8A
Receptors, Interleukin-8B
Grant Support
ID/Acronym/Agency:
N01-CB-21075/CB/NCI NIH HHS; N01-CO-74101/CO/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Interleukin; 0/Receptors, Interleukin-8A; 0/Receptors, Interleukin-8B; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Assignment of the human RT6 gene to 11q13 by PCR screening of somatic cell hybrids and in situ hybri...
Next Document:  Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatel...