| The murine gammaherpesvirus-68 chemokine-binding protein M3 inhibits experimental autoimmune encephalomyelitis. | |
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MedLine Citation:
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PMID: 20537410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chemokines are critical mediators of immune cell entry into the central nervous system (CNS), as occurs in neuroinflammatory disease such as multiple sclerosis. Chemokines are also implicated in the immune response to viral infections. Many viruses encode proteins that mimic or block chemokine actions, in order to evade host immune responses. The murine gammaherpesvirus-68 encodes a chemokine-binding protein called M3, which has unique biochemical features that enable it to bind to and inhibit an unusually broad range of chemokines. We applied a replication-defective adenoviral vector encoding M3 (AdM3) directly to the CNS to evaluate the capacity of this protein to inhibit neuroinflammation using the experimental autoimmune encephalomyelitis (EAE) model. Treatment with the AdM3 vector significantly reduced the clinical severity of EAE, attenuated CNS histopathology, and reduced numbers of immune cells infiltrating the CNS. These results suggest that M3 may represent a novel therapeutic approach to neuroinflammatory disease. |
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Authors:
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Jason M Millward; Peter J Holst; Mette Høgh-Petersen; Allan R Thomsen; Jan P Christensen; Trevor Owens |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 224 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Neuroimmunology Unit, Montreal Neurological Institute, 3801 University Street, Room 111, McGill University, Montreal, Quebec, Canada. jason.millward@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics Animals Cell Line Cell Migration Inhibition / genetics, immunology Chemokines / antagonists & inhibitors, metabolism* Encephalomyelitis, Autoimmune, Experimental / genetics, immunology*, therapy*, virology Female Gene Therapy / methods* Gene Transfer Techniques* Genetic Vectors / genetics, therapeutic use Humans Mice Mice, Inbred C57BL Protein Binding / immunology Rhadinovirus / genetics, immunology* Severity of Illness Index Treatment Outcome Viral Proteins / genetics, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/M3 protein, Murine gammaherpesvirus; 0/Viral Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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