Document Detail


The murine Xe169 gene escapes X-inactivation like its human homologue.
MedLine Citation:
PMID:  7951318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among a number of genes that escape X-chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X-inactivation. We report here the cloning and expression studies of a novel mouse gene, Xe169, and show that it escapes X-inactivation like its human homologue. Xe169 was assigned to band F2/F3 on the mouse X chromosome by fluorescent in situ hybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome. In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes. Xe169 is the first cloned non-pseudoautosomal gene that escapes X-inactivation in mice.
Authors:
J Wu; E C Salido; P H Yen; T K Mohandas; H H Heng; L C Tsui; J Park; V M Chapman; L J Shapiro
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature genetics     Volume:  7     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-12-29     Completed Date:  1994-12-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of California, San Francisco 94143.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/L29563;  L29564
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosome Mapping
Cloning, Molecular
Cricetinae
DNA Primers / genetics
DNA, Complementary / genetics
Dosage Compensation, Genetic*
Female
Humans
In Situ Hybridization, Fluorescence
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Muridae
Sequence Homology, Nucleic Acid
Species Specificity
X Chromosome
Grant Support
ID/Acronym/Agency:
GM33160/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Complementary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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