Document Detail


A murine B-cell lymphoma induced by Gross virus.
MedLine Citation:
PMID:  6971147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A B-lymphocyte tumor (MLB-MN line) was induced by Gross murine leukemia virus in Slc:ddY mice, successively passaged in normal adult mice, and adapted to tissue culture. The surface marker expression of MLB-MN was examined and found to include several markers that are known to occur in normal B-lymphocytes. The cells bore surface immunoglobulin M, detected by indirect immunofluorescence staining, and Fc receptors and complement receptors, detected by rosette formation. Thy 1 antigen and secretion of immunoglobulin were lacking. These results have led us to postulate that the origin of the MLB-MN tumor was a late differentiation stage of the B-lymphocyte.
Authors:
M Numata; Y Mitsuboshi; K Nitta
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  41     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1492-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
AKR murine leukemia virus*
Abelson murine leukemia virus
Animals
B-Lymphocytes* / immunology
Cell Line
Cell Membrane / analysis,  immunology
Immunoglobulin M / analysis
Lymphoma / pathology*
Mice
Neoplasms, Experimental / pathology
Receptors, Complement / analysis
Receptors, Fc / analysis
Chemical
Reg. No./Substance:
0/Immunoglobulin M; 0/Receptors, Complement; 0/Receptors, Fc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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