Document Detail

A murine B-cell lymphoma induced by Gross virus.
MedLine Citation:
PMID:  6971147     Owner:  NLM     Status:  MEDLINE    
A B-lymphocyte tumor (MLB-MN line) was induced by Gross murine leukemia virus in Slc:ddY mice, successively passaged in normal adult mice, and adapted to tissue culture. The surface marker expression of MLB-MN was examined and found to include several markers that are known to occur in normal B-lymphocytes. The cells bore surface immunoglobulin M, detected by indirect immunofluorescence staining, and Fc receptors and complement receptors, detected by rosette formation. Thy 1 antigen and secretion of immunoglobulin were lacking. These results have led us to postulate that the origin of the MLB-MN tumor was a late differentiation stage of the B-lymphocyte.
M Numata; Y Mitsuboshi; K Nitta
Related Documents :
21711207 - A composite renal tumor - metanephric adenofibroma, wilms tumor and renal cell carcinom...
25413617 - Apparent diffusion coefficient of intracranial germ cell tumors.
17056587 - Gene transfer of tumor-reactive tcr confers both high avidity and tumor reactivity to n...
9212047 - Hla-a2402-restricted and tumor-specific cytotoxic t lymphocytes from tumor-infiltrating...
8301347 - Brain metastasis from clear cell sarcoma of the kidney--a case report and review of the...
1739137 - Establishment and characterization of five new human renal tumor xenografts.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  41     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1492-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
AKR murine leukemia virus*
Abelson murine leukemia virus
B-Lymphocytes* / immunology
Cell Line
Cell Membrane / analysis,  immunology
Immunoglobulin M / analysis
Lymphoma / pathology*
Neoplasms, Experimental / pathology
Receptors, Complement / analysis
Receptors, Fc / analysis
Reg. No./Substance:
0/Immunoglobulin M; 0/Receptors, Complement; 0/Receptors, Fc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of cell-mediated immunity in tumor eradication by hyperthermia.
Next Document:  Heterogeneity of human thymocytes and a malignant T-lymphoblast cell line, MOLT-3.