Document Detail

A multivariate statistical method for the establishment of maximum allowable exposure to toxic materials in the workplace.
MedLine Citation:
PMID:  6517075     Owner:  NLM     Status:  MEDLINE    
A model has been developed for setting standard limiting concentrations for toxic substances in the body fluid or tissues of industrial workers. The method is very flexible, and allows the use of either univariate or multivariate data, and of classification schemes which are either supervised, unsupervised, or partially supervised. An index of subclinical biological damage is derived which is used to determine an optimal limiting exposure level. The model is applied to the particular case of selecting a maximum allowable concentration of blood lead in workers in industrial settings where lead toxicity is a danger.
R B Goldstein; J S Silverberg; H F Martin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  6     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-73     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Environmental Exposure*
Erythrocyte Indices
Hemoglobins / analysis
Lead / blood,  toxicity
Maximum Allowable Concentration*
Middle Aged
Protoporphyrins / blood
Reg. No./Substance:
0/Hemoglobins; 0/Protoporphyrins; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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