| A multiscale model of venous thrombus formation with surface-mediated control of blood coagulation cascade. | |
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MedLine Citation:
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PMID: 20441735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combination of the extended multiscale model, new image processing algorithms, and biological experiments is used for studying the role of Factor VII (FVII) in venous thrombus formation. A detailed submodel of the tissue factor pathway of blood coagulation is introduced within the framework of the multiscale model to provide a detailed description of coagulation cascade. Surface reactions of the extrinsic coagulation pathway on membranes of platelets are studied under different flow conditions. It is shown that low levels of FVII in blood result in a significant delay in thrombin production, demonstrating that FVII plays an active role in promoting thrombus development at an early stage. |
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Authors:
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Zhiliang Xu; Joshua Lioi; Jian Mu; Malgorzata M Kamocka; Xiaomin Liu; Danny Z Chen; Elliot D Rosen; Mark Alber |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Biophysical journal Volume: 98 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-07-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
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Languages: eng Pagination: 1723-32 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Mathematics, University of Notre Dame, Notre Dame, Indiana, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation* Factor VII / metabolism Mice Models, Biological* Porosity Protein C / metabolism Thrombin / biosynthesis Venous Thrombosis / blood*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL073750-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protein C; 9001-25-6/Factor VII; EC 3.4.21.5/Thrombin |
| Comments/Corrections | |
Erratum In:
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Biophys J. 2010 Oct 6;99(7):2384-5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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