Document Detail


A multiscale model of the electrophysiological basis of the human electrogastrogram.
MedLine Citation:
PMID:  21044575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The motility of the stomach is coordinated by an electrical activity termed "slow waves", and slow-wave dysrhythmias contribute to motility disorders. One major method for clinically evaluating gastric dysrhythmias has been electrogastrography (EGG); however, the clinical utility of EGG is limited partly due to the uncertainty regarding its electrophysiological basis. In this study, a multiscale model of gastric slow waves was generated from a biophysically based continuum description of cellular electrical events, coupled with a subject-specific human stomach model and high-resolution electrical mapping data. The model was then applied using a forward-modeling approach, within an anatomical torso model, to define how slow wave activity summates to generate the EGG potentials. The simulated EGG potentials were shown to be spatially varying in amplitude (0.27-0.33 mV) and duration (9.2-15.3 s), and the sources of this variance were quantified with respect to the activation timings of the underlying slow wave activity. This model constitutes an improved theory of the electrophysiological basis of the EGG, and offers a framework for optimizing the placement of EGG electrodes, and for interpreting the EGG changes occurring in disease states.
Authors:
Peng Du; Gregory O'Grady; Leo K Cheng; Andrew J Pullan
Related Documents :
17354695 - A framework for registration, statistical characterization and classification of cortic...
18255755 - Hardware implementation of cmac neural network with reduced storage requirement.
24965655 - South greenland ice-sheet collapse during marine isotope stage 11.
19345985 - Influence of threshold value in the use of statistical methods for groundwater vulnerab...
17658585 - A predictive model for the home outdoor exposure to nitrogen dioxide.
16122895 - Direct determination of niflumic acid in a pharmaceutical gel by atr/ftir spectroscopy ...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biophysical journal     Volume:  99     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2011-01-28     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2784-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Biophysical Phenomena
Electrodiagnosis / methods,  statistics & numerical data
Electrophysiological Phenomena
Gastrointestinal Motility / physiology*
Humans
Membrane Potentials
Models, Anatomic
Models, Biological*
Stomach / anatomy & histology,  physiology
User-Computer Interface
Grant Support
ID/Acronym/Agency:
R01 DK064775/DK/NIDDK NIH HHS; R01 DK64775/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery.
Next Document:  Observation and kinematic description of long actin tracks induced by spherical beads.