Document Detail

A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.
MedLine Citation:
PMID:  20447409     Owner:  NLM     Status:  MEDLINE    
We present a novel computational model for maladaptive cardiac growth in which kinematic changes of the cardiac chambers are attributed to alterations in cytoskeletal architecture and in cellular morphology. We adopt the concept of finite volume growth characterized through the multiplicative decomposition of the deformation gradient into an elastic part and a growth part. The functional form of its growth tensor is correlated to sarcomerogenesis, the creation and deposition of new sarcomere units. In response to chronic volume-overload, an increased diastolic wall strain leads to the addition of sarcomeres in series, resulting in a relative increase in cardiomyocyte length, associated with eccentric hypertrophy and ventricular dilation. In response to chronic pressure-overload, an increased systolic wall stress leads to the addition of sacromeres in parallel, resulting in a relative increase in myocyte cross sectional area, associated with concentric hypertrophy and ventricular wall thickening. The continuum equations for both forms of maladaptive growth are discretized in space using a nonlinear finite element approach, and discretized in time using the implicit Euler backward scheme. We explore a generic bi-ventricular heart model in response to volume- and pressure-overload to demonstrate how local changes in cellular morphology translate into global alterations in cardiac form and function.
Serdar Göktepe; Oscar John Abilez; Kevin Kit Parker; Ellen Kuhl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-05-04
Journal Detail:
Title:  Journal of theoretical biology     Volume:  265     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-42     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Department of Mechanical Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA.
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MeSH Terms
Blood Pressure
Cardiomegaly / physiopathology*
Cytoskeleton / ultrastructure
Finite Element Analysis
Heart / growth & development*
Heart Ventricles / physiopathology
Models, Cardiovascular*
Sarcomeres / physiology*
Stress, Mechanical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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