Document Detail


The multiplicity of human formins: Expression patterns in cells and tissues.
MedLine Citation:
PMID:  23629878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formins are actin-binding proteins conserved across species from plants to humans. The formin family is defined by their common formin homology (FH2) domains. The 15 distinct human formins are involved in a broad range of cellular functions, including cell adhesion, cytokinesis, cell polarity, and cell morphogenesis. Their commonality is actin polymerization activity inherent to FH2 domains. Although still requiring much study, biochemical activity of formins has been carefully described. In contrast, much less is known of their activities in complex living systems. With the diversity of the formin family and the actin structures that they affect, an extensive future of study beckons. In this study, we report the expression level of all 15 formins in 22 different human cell and tissue types using quantitative real-time PCR. Identification of major themes in formin expression and documentation of expression profiles should facilitate the cellular study of formins.
Authors:
Elisabeth C Krainer; Jessica L Ouderkirk; Eric W Miller; Matthew R Miller; Akos T Mersich; Scott D Blystone
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-05-24
Journal Detail:
Title:  Cytoskeleton (Hoboken, N.J.)     Volume:  70     ISSN:  1949-3592     ISO Abbreviation:  Cytoskeleton (Hoboken)     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-09-16     Completed Date:  2014-03-27     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  101523844     Medline TA:  Cytoskeleton (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-38     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Adaptor Proteins, Signal Transducing / metabolism
Cytoskeletal Proteins / metabolism*
Humans
Intracellular Signaling Peptides and Proteins / metabolism
Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
DK79884/DK/NIDDK NIH HHS; R01 DK079884/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Adaptor Proteins, Signal Transducing; 0/Cytoskeletal Proteins; 0/DAAM1 protein, human; 0/DAAM2 protein, human; 0/FMNL1 protein, human; 0/FMNL2 protein, human; 0/FMNL3 protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/Proteins
Comments/Corrections

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