Document Detail

A multiple sclerosis-like illness in a man harboring the mtDNA 14484 mutation.
MedLine Citation:
PMID:  10098545     Owner:  NLM     Status:  MEDLINE    
In most cases of Leber's hereditary optic neuropathy (LHON) the only clinical manifestation is visual loss. A multiple sclerosis-like illness has been infrequently reported in association with LHON. Most patients are women harboring the mtDNA 11778 mutation. We present a young man with clinical and paraclinical evidence of a demyelinating process with profound bilateral visual loss who harbored the mtDNA 14484 mutation associated with LHON.
M T Bhatti; N J Newman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society     Volume:  19     ISSN:  1070-8022     ISO Abbreviation:  J Neuroophthalmol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-23     Completed Date:  1999-04-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9431308     Medline TA:  J Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Blindness / genetics
Brain / pathology
DNA, Mitochondrial / genetics*
Magnetic Resonance Imaging
Multiple Sclerosis / diagnosis,  genetics*
Optic Atrophies, Hereditary / diagnosis,  genetics*
Optic Nerve / pathology
Point Mutation*
Spinal Cord / pathology
Visual Acuity
Grant Support
Reg. No./Substance:
0/DNA, Mitochondrial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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