Document Detail


The multiple functions of Numb.
MedLine Citation:
PMID:  19944684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease.
Authors:
Alberto Gulino; Lucia Di Marcotullio; Isabella Screpanti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-11-26
Journal Detail:
Title:  Experimental cell research     Volume:  316     ISSN:  1090-2422     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-03-30     Revised Date:  2011-11-24    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  900-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Inc. All rights reserved.
Affiliation:
Department of Experimental Medicine, Sapienza University, 324 viale Regina Elena, 00161 Rome, Italy. alberto.gulino@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion / physiology
Cell Movement / physiology
Endocytosis / physiology
Humans
Membrane Proteins / chemistry,  genetics,  metabolism*
Mice
Neoplasms / metabolism
Nerve Tissue Proteins / chemistry,  genetics,  metabolism*
Protein Isoforms / chemistry,  genetics,  metabolism*
Signal Transduction / physiology
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
GGP07118//Telethon
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/Numb protein, mouse; 0/Protein Isoforms

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