| The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. | |
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MedLine Citation:
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PMID: 18508566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell cycle checkpoints are pivotal mechanisms safeguarding genome stability. Cells that harbor defects in checkpoints are predisposed to genome instability and neoplastic transformation. Two structurally-unrelated protein kinases, CHK1 and CHK2, are implicated in several major checkpoints of the cell cycle, providing a crucial linkage between the upstream sensors of the checkpoints and the cell cycle engine. Variations of the ATM/ATR-CHK1/CHK2-CDC25-CDK axis underlie the molecular basis of the replication checkpoint, the intra-S phase checkpoint, and the G2 DNA damage checkpoint. Although some aspects of the pathway remain contentious, the ATM/ATR-CHK1/CHK2-p53-p21CIP1/WAF1-CDK axis is believed to play an important role in the G1 DNA damage checkpoint. Recent data also reveal that CHK1 may play a role in the spindle-assembly checkpoint. Finally, CHK1 and CHK2 are implicated in linking the cell cycle to diverse processes such as senescence and the circadian cycle. In this review article, we provide an overview of how the multi-tasking nature of CHK1 and CHK2 is achieved in vertebrate cells. |
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Authors:
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Yue Chen; Randy Y C Poon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-05-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-09-19 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 5016-29 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle DNA Damage DNA Replication Genomic Instability / genetics* Humans Protein Kinases / genetics* Protein-Serine-Threonine Kinases / genetics* S Phase / genetics |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases; EC 2.7.1.11/checkpoint kinase 2; EC 2.7.11.1/Checkpoint kinase 1; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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