Document Detail

The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): new methods for more potent eHealth interventions.
MedLine Citation:
PMID:  17466815     Owner:  NLM     Status:  MEDLINE    
In this article two new methods for building and evaluating eHealth interventions are described. The first is the Multiphase Optimization Strategy (MOST). It consists of a screening phase, in which intervention components are efficiently identified for inclusion in an intervention or for rejection, based on their performance; a refining phase, in which the selected components are fine tuned and issues such as optimal levels of each component are investigated; and a confirming phase, in which the optimized intervention, consisting of the selected components delivered at optimal levels, is evaluated in a standard randomized controlled trial. The second is the Sequential Multiple Assignment Randomized Trial (SMART), which is an innovative research design especially suited for building time-varying adaptive interventions. A SMART trial can be used to identify the best tailoring variables and decision rules for an adaptive intervention empirically. Both the MOST and SMART approaches use randomized experimentation to enable valid inferences. When properly implemented, these approaches will lead to the development of more potent eHealth interventions.
Linda M Collins; Susan A Murphy; Victor Strecher
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of preventive medicine     Volume:  32     ISSN:  0749-3797     ISO Abbreviation:  Am J Prev Med     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-07-19     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8704773     Medline TA:  Am J Prev Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S112-8     Citation Subset:  IM    
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MeSH Terms
Medical Informatics / organization & administration*
Program Development / methods*
Program Evaluation / methods*
United States
Grant Support
K02 DA015674/DA/NIDA NIH HHS; K02 DA015674-05/DA/NIDA NIH HHS; K02 DA15674/DA/NIDA NIH HHS; K05 DA018206/DA/NIDA NIH HHS; K05 DA018206/DA/NIDA NIH HHS; K05 DA018206-03/DA/NIDA NIH HHS; P50 CA101451/CA/NCI NIH HHS; P50 CA101451-04/CA/NCI NIH HHS; P50 DA010075/DA/NIDA NIH HHS; P50 DA010075-10/DA/NIDA NIH HHS; P50 DA10075/DA/NIDA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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