Document Detail

A multinational case-control study of cardiovascular disease and steroid hormone contraceptives. Description and validation of methods. World Health Organization Collaborative Study of Cardiovascular and Steroid Hormone Contraception.
MedLine Citation:
PMID:  8543965     Owner:  NLM     Status:  MEDLINE    
A hospital-based, case-control study of the association between current usage of oral contraceptives and first-time cases of acute myocardial infarction, stroke, or a venous thromboembolic event (deep vein thrombosis or pulmonary embolus) was carried out in 17 countries from four regions (Africa, Asia, Europe, and Latin America). A total of 3792 cases and 10,281 hospitalised controls matched for age were recruited during a 4-year period, ending in June 1993. The study was designed to have sufficient power to detect a relative risk of 2 for developing each of the three study diseases, associated with current oral contraceptive use in each of the four regions, with the exception of acute myocardial infarction (for which all non-European regions were to be combined) and for venous thromboembolic events in Asia, where these disorders are rare. This report describes the background, pilot study, methods, and the analyses carried out to validate the methods used in the study.
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  48     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-02-09     Completed Date:  1996-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1513-47     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Case-Control Studies
Cerebrovascular Disorders / chemically induced*,  epidemiology
Contraceptives, Oral, Hormonal / adverse effects*
Epidemiologic Methods*
Myocardial Infarction / chemically induced*,  epidemiology
Pilot Projects
Reproducibility of Results
Risk Factors
Thrombophlebitis / chemically induced*,  epidemiology
World Health Organization
Reg. No./Substance:
0/Contraceptives, Oral, Hormonal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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