Document Detail

A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late-life moderated by the environment.
MedLine Citation:
PMID:  17967500     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to clarify the relationship between the APOE alleles and depressive symptoms of older adults, considering individual characteristics and the effect of neighborhood environment. METHODS: Using a multilevel, stratified sampling strategy, 500 elders were recruited from official household records. Depressive symptoms were assessed using the Taiwanese Depression Questionnaire [TDQ]. Cognitive function was assessed by the Short Portable Mental Status Questionnaire [SPMSQ]. Blood samples were collected for the determination of the Apolipoprotein E [APOE] polymorphism. Perceived neighborhood experience was brought together using the Neighborhood Quality Index [NQI]. RESULTS: Three hundred and three subjects (58.8% male, with a mean age of 69.2 [SD=2.7] years) completed all questionnaires and the collection of blood samples. Risk factors for depressive symptoms of elders included lower educational level, cognitive impairment, having 2 or more chronic diseases, and having the APOE epsilon4 allele. In the 2-level model with individual characteristics and neighborhood environmental factors, the effect of the APOE epsilon4 allele on depressive symptoms was significantly attenuated. CONCLUSIONS: The APOE epsilon4 allele is correlated with depressive symptoms among older adults, but moderated by neighborhood environmental factors.
Yung-Chieh Yen; George W Rebok; Ming-Jen Yang; For-Wey Lung
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-10-04
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  32     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Calo Psychiatric Center, Pingtung County, Taiwan.
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MeSH Terms
Age Factors
Apolipoprotein E4 / genetics*
Cognition Disorders / diagnosis,  epidemiology
Depressive Disorder, Major / diagnosis,  epidemiology,  genetics*
Gene Frequency / genetics
Geriatric Assessment
Health Status
Polymorphism, Genetic / genetics*
Quality of Life / psychology
Residence Characteristics / classification*
Risk Factors
Social Environment*
Taiwan / epidemiology
Reg. No./Substance:
0/Apolipoprotein E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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