| A multilevel analysis of the influence of Apolipoprotein E genotypes on depressive symptoms in late-life moderated by the environment. | |
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MedLine Citation:
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PMID: 17967500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to clarify the relationship between the APOE alleles and depressive symptoms of older adults, considering individual characteristics and the effect of neighborhood environment. METHODS: Using a multilevel, stratified sampling strategy, 500 elders were recruited from official household records. Depressive symptoms were assessed using the Taiwanese Depression Questionnaire [TDQ]. Cognitive function was assessed by the Short Portable Mental Status Questionnaire [SPMSQ]. Blood samples were collected for the determination of the Apolipoprotein E [APOE] polymorphism. Perceived neighborhood experience was brought together using the Neighborhood Quality Index [NQI]. RESULTS: Three hundred and three subjects (58.8% male, with a mean age of 69.2 [SD=2.7] years) completed all questionnaires and the collection of blood samples. Risk factors for depressive symptoms of elders included lower educational level, cognitive impairment, having 2 or more chronic diseases, and having the APOE epsilon4 allele. In the 2-level model with individual characteristics and neighborhood environmental factors, the effect of the APOE epsilon4 allele on depressive symptoms was significantly attenuated. CONCLUSIONS: The APOE epsilon4 allele is correlated with depressive symptoms among older adults, but moderated by neighborhood environmental factors. |
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Authors:
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Yung-Chieh Yen; George W Rebok; Ming-Jen Yang; For-Wey Lung |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-10-04 |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 32 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 479-86 Citation Subset: IM |
Affiliation:
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Calo Psychiatric Center, Pingtung County, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Apolipoprotein E4 / genetics* Cognition Disorders / diagnosis, epidemiology Comorbidity Depressive Disorder, Major / diagnosis, epidemiology, genetics* Female Gene Frequency / genetics Genotype Geriatric Assessment Health Status Humans Male Polymorphism, Genetic / genetics* Quality of Life / psychology Questionnaires Residence Characteristics / classification* Risk Factors Social Environment* Taiwan / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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