Document Detail

The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes.
MedLine Citation:
PMID:  14555237     Owner:  NLM     Status:  MEDLINE    
PEA-15 is a small protein (15 kDa) that was first identified as an abundant phosphoprotein in brain astrocytes [Araujo et al., J Biol Chem 1993;268(8):5911-20], and subsequently shown to be widely expressed in different tissues and highly conserved among mammals [Estelles et al., J Biol Chem 1996;271(25):14800-6; Danziger et al., J Neurochem 1995;64(3):1016-25]. It is composed of a N-terminal death effector domain and a C-terminal tail of irregular structure. PEA-15 is regulated by multiple calcium-dependent phosphorylation pathways that account for its different forms: a non-phosphorylated form in equilibrium with a mono and a biphosphorylated variety. This already suggested that PEA-15 may play a major role in signal integration. Accordingly, it has been demonstrated to modulate signaling pathways that control apoptosis and cell proliferation. In particular, PEA-15 diverts astrocytes from TNFalpha-triggered apoptosis and regulates the actions of the ERK MAP kinase cascade by binding to ERK and altering its subcellular localization. The three-dimensional structure of PEA-15 has been modelized and recently determined using NMR spectroscopy, and may help to understand the various functions played by the protein through its molecular interactions.
François Renault; Etienne Formstecher; Isabelle Callebaut; Marie-Pierre Junier; Hervé Chneiweiss
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  66     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2003-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1581-8     Citation Subset:  IM    
INSERM U114, Collège de France, 11 Place Marcelin Berthelot, 75231 Paris Cedex 05, France.
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MeSH Terms
Apoptosis / physiology*
Astrocytes / cytology*,  metabolism
Cell Cycle / physiology
Intracellular Signaling Peptides and Proteins
Phosphoproteins / genetics,  physiology*
Transcription, Genetic
Tumor Necrosis Factor-alpha / physiology
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/PEA15 protein, human; 0/Phosphoproteins; 0/Tumor Necrosis Factor-alpha

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