| A multifaceted role for polyamines in bacterial pathogens. | |
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MedLine Citation:
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PMID: 18405343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyamines are polycationic molecules with a hydrocarbon backbone and multiple amino groups. Descriptions of the physiological roles of polyamines have often been limited to their interaction with negatively charged nucleic acids. Of late, reports linking polyamines to microbial carcinogenesis, biofilm formation, escape from phagolysosomes, bacteriocin production, toxin activity and protection from oxidative and acid stress have been published, providing insights about their other important but lesser known functions. This review focuses on recently discovered novel functions of polyamines in microorganisms, with an emphasis on bacterial pathogens of humans. |
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Authors:
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Pratik Shah; Edwin Swiatlo |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-03-05 |
Journal Detail:
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Title: Molecular microbiology Volume: 68 ISSN: 1365-2958 ISO Abbreviation: Mol. Microbiol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712028 Medline TA: Mol Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 4-16 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Mississippi Medical Center, 2500 N. State Street Jackson, MS 39216, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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metabolism Apoptosis Bacteria / metabolism, pathogenicity* Bacterial Adhesion Bacterial Proteins / metabolism Cadaverine / biosynthesis Humans Nucleic Acids / metabolism Phagosomes / microbiology Polyamines / chemistry, metabolism* Virulence |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Bacterial Proteins; 0/Nucleic Acids; 0/Polyamines; 462-94-2/Cadaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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