| The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis. | |
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MedLine Citation:
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PMID: 20681025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The three colony-stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte colony-stimulating factor (G-CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM-CSF and M-CSF, G-CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G-CSF, endogenous G-CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G-CSF in immunomodulation and intestinal immune homeostasis. |
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Authors:
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Andrew Martins; Jiahuai Han; Sung O Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: IUBMB life Volume: 62 ISSN: 1521-6551 ISO Abbreviation: IUBMB Life Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-11-15 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 100888706 Medline TA: IUBMB Life Country: England |
Other Details:
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Languages: eng Pagination: 611-7 Citation Subset: IM |
Copyright Information:
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(c) 2010 IUBMB |
Affiliation:
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Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Granulocyte Colony-Stimulating Factor / physiology* Homeostasis / immunology* Humans Immunomodulation Intestines / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI41637/AI/NIAID NIH HHS; AI68896/AI/NIAID NIH HHS; R01 AI041637-12/AI/NIAID NIH HHS; R01 AI041637-14/AI/NIAID NIH HHS; R01 AI068896-04/AI/NIAID NIH HHS; R01 AI068896-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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143011-72-7/Granulocyte Colony-Stimulating Factor |
| Comments/Corrections | |
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