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A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma.
MedLine Citation:
PMID:  22099725     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer.
Authors:
Tamar Stone; Alexandra Berger; Sheila Blumberg; Daniel O'Neill; Frank Ross; Alexander McMeeking; Weiliam Chen; Irena Pastar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
T Stone, PA, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA A Berger, BS, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA S Blumberg, MD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA F Ross, MD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA W Chen, PhD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA I Pastar, PhD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016 D O'Neill, MD, Department of Anesthesiology, New York University School of Medicine New York, NY 10016, USA A McMeeking, MD, Department of Medicine, New York University School of Medicine New York, NY 10016, USA.
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