| A multidisciplinary team approach to hydroxyurea-associated chronic wound with squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 22099725 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hydroxyurea (HU) has been shown to induce a variety of cutaneous adverse reactions, including severe leg ulcers. This report shows a successful treatment of a HU-induced chronic wound associated with squamous cell carcinomas (SCC). A 62-year-old patient affected with polycythemia vera and treated with HU for 10 years, presented with a non healing ulcer on a left heel. The patient gave a history of suffering from the wound for over 2 years. Biopsy showed evidence of invasive SCC. The patient underwent Mohs surgery and a greater saphenous vein ablation for polycythemia vera-associated vascular complications. The wound consistently decreased in size following successive debridements and coverage with human skin equivalent. The wound healed completely after a 6-month period. A multidisciplinary team approach to the treatment proved to be effective resulting in healing of this multifactorial chronic ulcer. |
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Authors:
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Tamar Stone; Alexandra Berger; Sheila Blumberg; Daniel O'Neill; Frank Ross; Alexander McMeeking; Weiliam Chen; Irena Pastar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-17 |
Journal Detail:
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Title: International wound journal Volume: - ISSN: 1742-481X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101230907 Medline TA: Int Wound J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc. |
Affiliation:
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T Stone, PA, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA A Berger, BS, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA S Blumberg, MD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA F Ross, MD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA W Chen, PhD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016, USA I Pastar, PhD, Department of Surgery, Helen and Martin Kimmel Wound Center, New York University School of Medicine New York, NY 10016 D O'Neill, MD, Department of Anesthesiology, New York University School of Medicine New York, NY 10016, USA A McMeeking, MD, Department of Medicine, New York University School of Medicine New York, NY 10016, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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