Document Detail

A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labour.
MedLine Citation:
PMID:  11139532     Owner:  NLM     Status:  MEDLINE    
Postpartum haemorrhage accounts for nearly 28% of maternal mortality in developing countries. Syntometrine is an effective and commonly used oxytocic in preventing postpartum haemorrhage, but it requires a controlled storage environment and i.m. administration. Misoprostol is an orally active uterotonic agent. A total of 2058 patients having a singleton pregnancy, low risk for postpartum haemorrhage and vaginal delivery were randomized to receive either 1 ml syntometrine or 600 microgram misoprostol for the management of the third stage of labour. There were no significant differences between the two groups in the mean blood loss, the incidence of postpartum haemorrhage and the fall in haemoglobin concentration. The need for additional oxytocic injection was significantly higher in the misoprostol group [relative risk (RR) 1.62, 95% confidence interval (CI) 1.34-1.96], but that of manual removal of placenta was reduced (RR 0.29, 95% CI 0.09-0.87). Shivering and transient pyrexia were more common in the misoprostol group. Oral misoprostol might be used in the management of the third stage, especially in situations where the use of syntometrine is contraindicated and facilities for storage and parenteral administration of oxytocics are limited.
P S Ng; A S Chan; W K Sin; L C Tang; K B Cheung; P M Yuen
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  16     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-03-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-35     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
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MeSH Terms
Administration, Oral
Ergonovine / administration & dosage*
Hemoglobins / analysis
Injections, Intramuscular
Labor Stage, Third / drug effects*
Misoprostol / administration & dosage*
Oxytocics / administration & dosage*
Oxytocin / administration & dosage*
Postpartum Hemorrhage / prevention & control*
Reg. No./Substance:
0/Hemoglobins; 0/Oxytocics; 37209-62-4/syntometrine; 50-56-6/Oxytocin; 59122-46-2/Misoprostol; 60-79-7/Ergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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