| A multicenter study on extramammary Paget's disease in Korea. | |
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MedLine Citation:
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PMID: 21506963 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. Methods The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. Results As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). Conclusions In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies. |
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Authors:
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Seok-Jong Lee; Yoon Seok Choe; Hong Dae Jung; Sung Ku Ahn; Young Chang Cha; Kwang Hyun Cho; Hae Young Choi; Kee Yang Chung; Chang Hun Huh; Il Hwan Kim; Ki-Ho Kim; Moon Bum Kim; Myung Hwa Kim; You Chan Kim; Jee Bum Lee; Mi Woo Lee; Min-Geol Lee; Weon Ju Lee; Dong Hoon Shin; Jeong-Hyun Shin; Kee Suck Suh; Young Ho Won; |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: International journal of dermatology Volume: 50 ISSN: 1365-4632 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: 508-515 Citation Subset: - |
Copyright Information:
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© 2011 The International Society of Dermatology. |
Affiliation:
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Department of Dermatology, Kyungpook National University, Daegu Department of Dermatology, Yonsei University Wonju, Wonju Department of Dermatology, Keimyung University, Daegu Department of Dermatology, Seoul National University, Seoul Department of Dermatology, Ewha Women's University, Seoul Department of Dermatology, Yonsei University, Seoul Department of Dermatology, Korea University, Ansan Department of Dermatology, Dong-A University, Busan Department of Dermatology, Pusan National University, Busan Department of Dermatology, Dankook University, Cheonan Department of Dermatology, Ajou University, Suwon Department of Dermatology, Chonnam National University, Gwangju Department of Dermatology, University of Ulsan, Ulsan Department of Dermatology, Yeungnam University, Daegu Department of Dermatology, Inha University, Incheon Department of Dermatology, Kosin University, Busan, South Korea. |
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