| A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. | |
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MedLine Citation:
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PMID: 20053470 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Individuals with hypertension and hyperuricemia have an increased risk of coronary artery disease and cerebral vascular disease as compared to patients with normal uric acid levels. Our aim is to determine the prevalence of hyperuricemia in hypertensive patients in Taiwan, and whether serum uric acid (SUA) is associated with changes in renal function in patients with hypertension. METHODS: We studied 2145 hypertensive patients receiving medical treatment, assessed the prevalence of hyperuricemia, and determined the independent risk factors for SUA. Simple correlation and multiple regression analyses were applied to identify the independent risk factors for SUA increase. Logistic regression analysis was used to estimate the association between 4 quartiles of SUA level and correspondent serum creatinine (SCr) concentrations. RESULTS: Hypertensive subjects had a high prevalence of hyperuricemia (men, 35%; women, 43%). SUA was significantly associated with the independent risk factors of SCr, diuretic usage, and diabetes (inversely related) in both genders, whereas β-blocker usage and body mass index were only associated in men. Multiple logistic regression models showed that in the non-diuretic user group the highest SUA quartile entailed >4 times greater risk for SCr elevation than the lowest. In the diuretic user group, a >2 times greater risk was noted. CONCLUSIONS: Hyperuricemia hypertensive subjects demonstrated a corresponding elevation of SUA and SCr irrespective of diuretic use. Elevation of SUA, in addition to SCr, may represent a progression of renal function impairment. |
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Authors:
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Chung-Sheng Lin; Yi-Jen Hung; Gau-Yang Chen; Thing-Fong Tzeng; Du-Yi Lee; Cheng-Yun Chen; Wen-Pin Huang; Chin-Hsung Huang |
Publication Detail:
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Type: Journal Article Date: 2010-01-06 |
Journal Detail:
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Title: International journal of cardiology Volume: 148 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Chung Shan Medical University Hospital, 110, Section 1, Chien Kuo North Road, Taichung, 402, Taiwan; School of Medicine, Chung Shan Medical University, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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