| A multicenter study about Neurobiology of Suicidal Behavior: design, development, and preliminary results. | |
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MedLine Citation:
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PMID: 16040576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The subproject 1.5 "Neurobiology of Suicidal Behavior" is a multicenter study assessing peripheral parameters of the serotonergic, noradrenergic, and dopaminergic transmitter systems. Additionally, stress hormones and the lipid system as well as inhibitory and excitatory amino acids will be investigated. The different parameters are collected in cerebral spinal fluid (CSF), blood, and saliva. Patients with a depressive spectrum disorder with and without a suicide attempt (during the last three weeks) and being medication free for two weeks are included in the study. So far, 103 patients and controls have been recruited. The design and development of this project as well as interconnections with the others subprojects are described. Preliminary results about the stress hormone system and suicidality are presented. |
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Authors:
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Thomas Bronisch; Jürgen Brunner; Brigitta Bondy; Dan Rujescu; Gerd Bishof; Isabella Heuser; Bruno Müller-Oerlinghausen; Barbara Hawellek; Wolfgang Maier; Marie Luise Rao; Werner Felber; Ute Lewitzka; Jochen Oehler; Andreas Broocks; Fritz Hohagen; Erik Lauterbach |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of suicide research : official journal of the International Academy for Suicide Research Volume: 9 ISSN: 1381-1118 ISO Abbreviation: Arch Suicide Res Publication Date: 2005 |
Date Detail:
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Created Date: 2005-07-25 Completed Date: 2005-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9504451 Medline TA: Arch Suicide Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 19-26 Citation Subset: IM |
Affiliation:
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Max-Planck Institute of Psychiatry, Munich, Germany. bronisch@mpipsykl.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aggression
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psychology Anxiety* / cerebrospinal fluid, metabolism, physiopathology Brain / metabolism*, physiopathology* Depressive Disorder, Major* / cerebrospinal fluid, metabolism, physiopathology Dopamine / metabolism Follow-Up Studies Humans Hydrocortisone / metabolism Impulsive Behavior / psychology Lipid Metabolism Monoamine Oxidase / blood Norepinephrine / metabolism Prospective Studies Serotonin / metabolism* Suicide, Attempted / ethnology*, psychology* |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 50-67-9/Serotonin; 51-41-2/Norepinephrine; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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