Document Detail

A multicenter, randomized, double-blind study comparing a daily bedtime administration of famotidine and ranitidine in short-term treatment of active duodenal ulcer.
MedLine Citation:
PMID:  2670647     Owner:  NLM     Status:  MEDLINE    
The efficacy and safety of famotidine and ranitidine in the treatment of active duodenal ulcer were compared in a multicenter, randomized double-blind study. The study was carried out in 5 centers which included a total of 143 patients with endoscopically documented active duodenal ulcer. The patients received either famotidine (1 tablet of 40 mg at night) or ranitidine (2 tablets of 150 mg at night). Endoscopic examinations were performed at 4 and 6 weeks of active treatment. Day and nocturnal pain were also monitored and the laboratory and clinical profiles evaluated. One hundred and thirty-three patients fulfilled the evaluation criteria (66 patients in the famotidine group and 67 in the ranitidine group). Healing rates at weeks 4 or 6 of treatment showed no significant differences between the famotidine and the ranitidine groups. The healing rates were 79% at week 4 and 96% at week 6 in the famotidine group, and 77% at week 4 and 95% at week 6 in the ranitidine group. Similar results were observed in both treatment groups with regard to pain resolution, decrease in antacid intake and safety profile.
R Alcalá-Santaella; J Guardia; J Pajares; J Piqué; L Pita; E Alvárez; P Castellanos; L Guarner; J Ortiz; R Pesquera
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Duplicate Publication; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Digestion     Volume:  42     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-29     Completed Date:  1989-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Hospital Gregorio Marañón, Madrid, España.
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MeSH Terms
Anti-Ulcer Agents / administration & dosage*,  therapeutic use
Double-Blind Method
Drug Administration Schedule
Duodenal Ulcer / drug therapy*
Multicenter Studies as Topic
Random Allocation
Ranitidine / administration & dosage*,  therapeutic use
Thiazoles / administration & dosage*,  therapeutic use
Time Factors
Wound Healing
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Thiazoles; 66357-35-5/Ranitidine; 76824-35-6/Famotidine
Comment In:
Digestion. 1989;44(4):237   [PMID:  2637217 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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