Document Detail


A multicenter randomized double-blind prospective study of the postoperative patient controlled intravenous analgesia effects of dezocine in elderly patients.
MedLine Citation:
PMID:  24753745     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The postoperative PCIA effects of dezocine in elderly patients were determined using a large multicenter randomized double-blind prospective study.
METHODS: A total of 279 patients were randomized into four groups: (1) Control group (C): 2 μg/kg sufentanil plus 10 mg metoclopramide. (2) Dezocine group 1 (D1): 1 μg/kg sufentanil plus 0.1 mg/kg dezocine plus 10 mg metoclopramide. (3) Dezocine group 2 (D2): 1 μg/kg sufentanil plus 0.2 mg/kg dezocine plus 10 mg metoclopramide. (4) Dezocine group 3 (D3): 1 μg/kg sufentanil plus 0.3 mg/kg dezocine plus 10 mg metoclopramide. The index during operation including MAP, HR, SpO2, ETCO2, CVP, and BIS were determined. Analgesia effects including HR, MAP, RR, SpO2, pressing times of PCA demand, pressing times of PCR delivery, total amount of drug, additional sufentanil, VAS at rest and during moving, Ramsay sedation score, and BCS were repeated measured 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. Overall satisfaction index and the side-effects including nausea, urinary retention, skin pruritus and respiratory depression were evaluated 1 h, 3 h, 6 h, 24 h, and 48 h after surgery.
RESULTS: Dezocine combining with sufentanil is complement for sufentanil in PCIA at least in its analgesia effects after surgery. Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg combining with sufentanil (1 μg/kg) has limited side effects as sufentanil (2 μg/kg) in PCIA. Sufentanil (1 μg/kg) combining Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg is better than combining Dezocine at a dosage of 0.3 mg/kg in PCIA at least in Overall satisfaction index.
CONCLUSION: Dezocine combining with sufentanil is a complement drug for sufentanil in PCIA. Considering the side effects and overall satisfaction index, 0.1 mg/kg seems to be an ideal dosage for Dezocine using in the postoperative PCIA in elderly patients.
Authors:
Chunying Wang; Lizhi Li; Boxiong Shen; Hui Jiang; Lan Yuan; Dongping Shi; Junfeng Zhu; Xuan Guo; Hua Li
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Publication Detail:
Type:  Journal Article     Date:  2014-03-15
Journal Detail:
Title:  International journal of clinical and experimental medicine     Volume:  7     ISSN:  1940-5901     ISO Abbreviation:  Int J Clin Exp Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-04-22     Completed Date:  2014-04-22     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  101471010     Medline TA:  Int J Clin Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  530-9     Citation Subset:  -    
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