| A multicenter evaluation of levobunolol (Vistagan) in Germany. | |
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MedLine Citation:
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PMID: 3054684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the efficacy and safety of 0.5% levobunolol HC1 (Vistagan) in 2,041 glaucoma patients at 143 sites in the Federal Republic of Germany. This study was a 3-month, open-label, noncomparative trial of levobunolol administered twice daily. Eighty-five percent of the patients completed the study period with well-controlled intraocular pressure (IOP). Treatment was discontinued in the remaining 15%: 7% for adverse reactions, 1% for lack of drug efficacy, and 7% for reasons unrelated to the study treatment. Efficacy, ocular drug tolerance, and systemic safety were judged as good to very good in approximately 80% of the patients. This large, postapproval study confirms previous findings of several well-controlled clinical trials indicating that levobunolol is an effective drug for the treatment of elevated IOP and is safe and comfortable for most patients. |
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Authors:
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G D Novack; E P Kelley; J C Lue |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde Volume: 197 ISSN: 0030-3755 ISO Abbreviation: Ophthalmologica Publication Date: 1988 |
Date Detail:
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Created Date: 1988-11-30 Completed Date: 1988-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0054655 Medline TA: Ophthalmologica Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 90-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology Clinical Research, Allergan Pharmaceuticals, Irvine, Calif. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Administration Schedule Drug Evaluation Drug Hypersensitivity / etiology Germany, West Glaucoma / drug therapy* Humans Levobunolol / administration & dosage, adverse effects, therapeutic use* Multicenter Studies as Topic |
| Chemical | |
Reg. No./Substance:
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47141-42-4/Levobunolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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