| A multicenter evaluation of intramuscular ritodrine hydrochloride as initial parenteral therapy for preterm labor management. | |
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MedLine Citation:
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PMID: 7830157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety-four patients in documented preterm labor received three intramuscular injections of ritodrine hydrochloride over an interval of 6 hours. They subsequently received the tocolytic agent intravenously for a minimum of 6 hours. The effects of ritodrine on uterine activity and the cardiovascular system were determined. Intramuscular ritodrine hydrochloride elicited a prompt and sustained reduction in the frequency of uterine contractions. The transition to intravenous treatment was achieved without an increase in uterine activity. Seventy percent of the patients had a sustained interval of uterine quiescence, and 96% had at least a 24-hour delay in delivery. Initial parenteral therapy with intramuscular ritodrine hydrochloride is safe and effective and may provide an alternative to intravenous therapy and a means of managing preterm labor during interhospital transport of a patient. |
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Authors:
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T J Benedetti; B Gonik; R H Hayashi; H J Adams |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 14 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 1994 Sep-Oct |
Date Detail:
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Created Date: 1995-02-23 Completed Date: 1995-02-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 403-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Washington Medical Center, Seattle 98195. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Drug Administration Schedule Female Humans Injections, Intramuscular Life Tables Obstetric Labor, Premature / prevention & control* Pregnancy Prospective Studies Ritodrine / administration & dosage*, therapeutic use Time Factors Tocolysis* |
| Chemical | |
Reg. No./Substance:
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26652-09-5/Ritodrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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