| A multicenter, double-blind, randomized controlled study of omeprazole versus ranitidine in the treatment of duodenal ulcer in Israel. | |
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MedLine Citation:
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PMID: 7960688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multicenter, double-blind, randomized, controlled study of 203 Israeli patients with endoscopically proven duodenal ulcer is described. The study compares the efficacy (i.e., ulcer healing and relief of symptoms) and safety of 20 mg omeprazole once daily in the morning, with those of 300 mg ranitidine once daily at night. The omeprazole group had significantly higher cumulative healing rates than the ranitidine group both at day 15 (71% vs. 55%, P < 0.03) and day 29 (94% vs. 86%, P < 0.05). The efficacy was unaffected by known risk factors such as smoking. The omeprazole group had significantly fewer days with pain than the ranitidine group (median 1 vs. 3.5 days) (P < 0.03). There were no differences in ulcer size, symptoms or healing rates between Ashkenazi and Sephardic patients who were born in Israel, or who had immigrated to Israel. In summary, the present study confirms the efficacy and safety of omeprazole in the treatment of duodenal ulcer. Omeprazole provides more rapid relief of the symptoms and heals a greater proportion of duodenal ulcers, within 2-4 weeks, than ranitidine. |
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Authors:
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N Arber; Y Avni; R Eliakim; A Swissa; E Melzer; D Rachmilewitz; F Konikoff |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Israel journal of medical sciences Volume: 30 ISSN: 0021-2180 ISO Abbreviation: Isr. J. Med. Sci. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-12-14 Completed Date: 1994-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0013105 Medline TA: Isr J Med Sci Country: ISRAEL |
Other Details:
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Languages: eng Pagination: 757-61 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Sourasky Medical Center (Ichilov Hospital), Tel Aviv, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Double-Blind Method Drug Administration Schedule Duodenal Ulcer / drug therapy* Female Humans Israel Male Middle Aged Omeprazole / administration & dosage, therapeutic use* Pain / prevention & control Prospective Studies Ranitidine / administration & dosage, therapeutic use* Safety Smoking |
| Chemical | |
Reg. No./Substance:
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66357-35-5/Ranitidine; 73590-58-6/Omeprazole |
| Comments/Corrections | |
Comment In:
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Isr J Med Sci. 1994 Oct;30(10):784-6
[PMID:
7960694
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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