Document Detail


A multicenter double blind clinical trial on 3.4.5-trimethoxybenzoiyl-epsilon-aminocaproic acid (C-3) in acute myocardial infarction.
MedLine Citation:
PMID:  1222886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
186 out of 391 patients with acute myocardial infarction were treated with C-3 and 205 with placebo in a multicenter, double-blind clinical trial. Ensuing complications were treated in the same way in both groups. C-3 was injected i.v. slowly at the dose of 2 g statim plus 6 g by continuous drip infusion over 24 hrs for 5 days. During treatment, clinical progress was influenced only in regard to cardiac failure since in the C-3 group the improvement was more significant than in the placebo one (P less than 0.0025). Mortality rates were 8.1% and 11.2% for the C-3 and placebo groups, respectively. The difference in mortality was significant (P less than 0.05) for patients treated with C-3 for more than 24 hours. Mortality in male patients treated with C-3 for more than 12 hours was significantly lower (P less than 0.025). In patients less than 60 years old mortality rate was significantly lower (P less than 0.05) and was more so in patients receiving C-3 for more than 12 hours (P less than 0.025). Mortality due to complications was lower in the C-3 group, with arrhythmias (9.8% vs 14.2%), cardiogenic shock (69.2% vs 75%), and cardiac failure (9% vs 19.4%). Results agree with the hypothesis that C-3 may be effective in acute myocardial infarction by improving the action of traditional antiarrhythmic drugs, and augmenting myocardial contraction energy.
Authors:
P Rossi; A Brusca; L di Pretoro; P F Fazzini; A Galassi; M Gentile; C Gramolini; M Lombardi; A Lotto; A Martinelli; G Palma; A Poppi; P I Porciello; P L Prati
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Giornale italiano di cardiologia     Volume:  5     ISSN:  0046-5968     ISO Abbreviation:  G Ital Cardiol     Publication Date:  1975  
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1270331     Medline TA:  G Ital Cardiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  914-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Age Factors
Aminocaproic Acids / therapeutic use*
Arrhythmias, Cardiac / etiology
Drug Evaluation
Humans
Male
Middle Aged
Myocardial Infarction / complications,  drug therapy*,  mortality
Shock, Cardiogenic / etiology
Chemical
Reg. No./Substance:
0/Aminocaproic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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