| A multicenter double blind clinical trial on 3.4.5-trimethoxybenzoiyl-epsilon-aminocaproic acid (C-3) in acute myocardial infarction. | |
MedLine Citation:
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PMID: 1222886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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186 out of 391 patients with acute myocardial infarction were treated with C-3 and 205 with placebo in a multicenter, double-blind clinical trial. Ensuing complications were treated in the same way in both groups. C-3 was injected i.v. slowly at the dose of 2 g statim plus 6 g by continuous drip infusion over 24 hrs for 5 days. During treatment, clinical progress was influenced only in regard to cardiac failure since in the C-3 group the improvement was more significant than in the placebo one (P less than 0.0025). Mortality rates were 8.1% and 11.2% for the C-3 and placebo groups, respectively. The difference in mortality was significant (P less than 0.05) for patients treated with C-3 for more than 24 hours. Mortality in male patients treated with C-3 for more than 12 hours was significantly lower (P less than 0.025). In patients less than 60 years old mortality rate was significantly lower (P less than 0.05) and was more so in patients receiving C-3 for more than 12 hours (P less than 0.025). Mortality due to complications was lower in the C-3 group, with arrhythmias (9.8% vs 14.2%), cardiogenic shock (69.2% vs 75%), and cardiac failure (9% vs 19.4%). Results agree with the hypothesis that C-3 may be effective in acute myocardial infarction by improving the action of traditional antiarrhythmic drugs, and augmenting myocardial contraction energy. |
Authors:
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P Rossi; A Brusca; L di Pretoro; P F Fazzini; A Galassi; M Gentile; C Gramolini; M Lombardi; A Lotto; A Martinelli; G Palma; A Poppi; P I Porciello; P L Prati |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Giornale italiano di cardiologia Volume: 5 ISSN: 0046-5968 ISO Abbreviation: G Ital Cardiol Publication Date: 1975 |
Date Detail:
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Created Date: 1976-07-06 Completed Date: 1976-07-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1270331 Medline TA: G Ital Cardiol Country: ITALY |
Other Details:
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Languages: eng Pagination: 914-22 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Age Factors Aminocaproic Acids / therapeutic use* Arrhythmias, Cardiac / etiology Drug Evaluation Humans Male Middle Aged Myocardial Infarction / complications, drug therapy*, mortality Shock, Cardiogenic / etiology |
| Chemical | |
Reg. No./Substance:
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0/Aminocaproic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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