Document Detail

A multi-site validation trial of radioactive seed localization as an alternative to wire localization.
MedLine Citation:
PMID:  18248562     Owner:  NLM     Status:  MEDLINE    
This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered "negative" if > or =2 mm from in-situ and invasive disease. Pain and convenience scores were recorded on a 10-point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p < 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p < 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re-excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.
Jenevieve H Hughes; Mark C Mason; Richard J Gray; Sarah A McLaughlin; Amy C Degnim; Jack T Fulmer; Barbara A Pockaj; Patricia J Karstaedt; Michael C Roarke
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Validation Studies     Date:  2008-01-31
Journal Detail:
Title:  The breast journal     Volume:  14     ISSN:  1524-4741     ISO Abbreviation:  Breast J     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505539     Medline TA:  Breast J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-7     Citation Subset:  IM    
Department of Surgery, Mayo Clinic, Scottsdale, Arizona 85259, USA.
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MeSH Terms
Biopsy / methods*
Breast / pathology*
Breast Neoplasms / diagnosis*,  radionuclide imaging,  surgery*
Iodine Radioisotopes / diagnostic use
Mastectomy, Segmental / methods*
Middle Aged
Reg. No./Substance:
0/Iodine Radioisotopes

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