Document Detail

A multi-case report of acute renal failure in patients treated with Aggrenox.
MedLine Citation:
PMID:  20664119     Owner:  NLM     Status:  In-Process    
BACKGROUND: Aggrenox is used in the secondary prevention of stroke. Acute renal failure, potentially associated with Aggrenox, has been observed in several patients.
OBJECTIVE: The objective of this study was to determine if Aggrenox was associated with acute renal failure and to determine whether it was acetylsalicylic acid, dipyridamole or the combination that led to decline in renal function.
METHODS: A case series of three patients suffering severe nausea, vomiting, diarrhea, renal dysfunction and clinical decline during Aggrenox therapy was examined. Serum creatinine and Blood Urea Nitrogen (BUN) were measured to evaluate renal function.
RESULTS: Analysis of this patient group revealed that Patient 1 experienced nausea, emesis, anorexia, diarrhea and significant clinical decline during treatment with Aggrenox. Patients 2 and 3 also presented with complaints of nausea and emesis. Lab measurements along with clinical symptoms indicated that all three patients experienced acute renal failure, having increases in serum creatinine of 186%, 144% and 249%, respectively. Symptoms and lab work returned to baseline following discontinuation of Aggrenox.
CONCLUSION: It is biologically plausible that Aggrenox may contribute to renal dysfunction in patients under certain pathophysiological circumstances.
Kerry Joy; Sacha Dubois; Carrie Gibbons; John Hargadon; Michel Bédard
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-06
Journal Detail:
Title:  Journal of population therapeutics and clinical pharmacology = Journal de la thérapeutique des populations et de la pharamcologie clinique     Volume:  17     ISSN:  1710-6222     ISO Abbreviation:  J Popul Ther Clin Pharmacol     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101530023     Medline TA:  J Popul Ther Clin Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e262-8     Citation Subset:  IM    
St. Joseph's Care Group, Thunder Bay, Ontario, Canada.
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