Document Detail


Is mucaine an appropriate medication for the relief of heartburn during pregnancy?
MedLine Citation:
PMID:  2099731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double blind comparative study comparing Mucaine, Mucaine without oxethazaine, and placebo was carried out with 50 patients with symptoms of heartburn during late pregnancy. We found that the 2 active treatments were more effective than placebo for the relief of heartburn, but there was no statistically significant difference between groups for the relief of nausea and regurgitation. There was a significant difference in the percentage of days of use of each medication, with the placebo being used least frequently. Although not statistically significant, for the 3 measures for which placebo differed from the active treatments, patients showed a better response to mucaine. This suggests that the addition of oxethazaine may be of benefit. The lack of statistical significance may be due to the relatively small number of cases, and the findings are promising. No side effects were recorded for any treatment.
Authors:
G T Kovacs; J Campbell; D Francis; D Hill; M A Adena
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asia-Oceania journal of obstetrics and gynaecology / AOFOG     Volume:  16     ISSN:  0389-2328     ISO Abbreviation:  Asia Oceania J Obstet Gynaecol     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2013-03-25    
Medline Journal Info:
Nlm Unique ID:  8102781     Medline TA:  Asia Oceania J Obstet Gynaecol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  357-62     Citation Subset:  IM    
Affiliation:
Family Planning Association of Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aluminum Hydroxide / therapeutic use*
Anti-Ulcer Agents / therapeutic use*
Double-Blind Method
Drug Combinations
Ethanolamines / therapeutic use*
Female
Heartburn / drug therapy*
Humans
Magnesium Hydroxide / therapeutic use*
Pregnancy
Pregnancy Complications / drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Drug Combinations; 0/Ethanolamines; 1309-42-8/Magnesium Hydroxide; 21645-51-2/Aluminum Hydroxide; 78371-69-4/Oxaine M; IP8QT76V17/oxethazaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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